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Welcome to the X-Ray Structure Biology Laboratory!


X-ray crystallography is one of the most powerful techniques to study the three-dimensional structures of biological macromolecules. The multi-user X-ray core facility at the Institute of Molecular Biology provides the instrumentation and expertise from X-ray diffraction data collection and processing to structure solution and refinement. The laboratory is equipped with state-of-the-art hardware and software to facilitate crystallography groups to determine their structures. We also provide periodical training courses in every stage of structure determination process for researchers who are interested in solving the structures of their favorite proteins.

The facility has a Rigaku Ultimate HomeLab™ protein crystallography system which would enable data collection on the widest range of protein crystal samples. The foundation for the versatility of this X-ray diffraction system is the FR-E+ SuperBright™ microfocus generator. When coupled with Osmic™ VariMax™ optics, the Ultimate HomeLab provides the highest possible usable flux available in a home laboratory source. Using the latest in microfocus technology, the FR-E+ SuperBright has a 70 x 70 micron anode focal spot. When coupled with an Osmic VariMax optic, this uniquely small focal spot leads to a small, monochromatic beam on the sample which is the perfect complement to optimize signal-to-noise for the small crystals used in today’s protein laboratories. The usable flux produced by the Ultimate HomeLab is up to 35 times greater than that of a conventional generator and optic, enabling the collection of quality data on small crystals that diffract too weakly on standard home sources.
Technical Specification of the Ultimate HomeLab system

FR-E+ SuperBright microfocus rotating anode generator
Osmic VariMax optics
R-AXIS IV++ two-IP system
Saturn 944+ CCD detector
Single φ vertical for R-AXIS IV++ detectors
AFC-11 4-axis partial χ goniometer for Saturn 944
CrystalClear™ for data collection
d*TREK® and HKL-2000® for data processing
Low temp:
X-stream 2000s on both ports for worry free sample cooling without liquid nitrogen
Contact Information:

You can use the online reservation system to obtain account and to make reservation.
If you are interested in our services, feel free to give the facility manager a call.
Contact: Dr. Chen, Shuenn
Tel: 2789-9225 

115 台北市南港區研究院路二段 128 號 Copyright©Academia Sinica 2010
128 Academia Road, Section 2, Nankang, Taipei 115, Taiwan