Core Facilities

To maximize the usage, the Institute made a decision to share expensive and/or sophisticated equipments ever since its establishment. Accordingly, core facilities have been organized and supervised by specialists. For example, the imaging core facility composed of several confocal microscopes and electron microscopes has been set up and has provided the necessary service for the acquisition and analysis of high resolution images. Other facilities, including X-ray, FACS, q-PCR, and transgenic mouse facilities, also accelerate the scientific progress in IMB.

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Animal Facility

Location - 6th Floor
Website - http://mouse.imb.sinica.edu.tw/AnimalFacility/
Contact - Yun-Tien Wu, garywu@gate.sinica.edu.tw, 2789-9234#400
Bioinformatics-Biology Service Core

Location - 4th Floor, N419
Website - http://bc.imb.sinica.edu.tw/
Contact - Chen-Hsin (Albert) Yu, albertchyu@gate.sinica.edu.tw; Hsin-Nan Lin (Arith), arith@gate.sinica.edu.tw, 2789-9967
Biophysics Core Facility

Location - 2th Floor, 202、217
Website - http://www.imb.sinica.edu.tw/en/research/core_facilities/biophysicals/
Contact - Shue-Shing Chen, shuenn@gate.sinica.edu.tw, 2789-9225
Description -

1. AVIV model 400 Circular Dichroism Spectrometer
2. Biacore X100
3. MicroCal iTC200
4. Crystal Phoenix - Protein crystallization system
5. Honeybee 961 - protein crystallization system
6. Desktop Minstel – Crystal imaging for protein crystallography
7. Dynamic Light Scattering (DLS) 8. FR-E+ SuperBright microfocus rotating anode generator - Osmic VariMax optics R-AXIS IV++ two-IP system & Saturn 944+ CCD detector

Booking System /　Xray Booking System
Computer Room

Location - 1th Floor, N106
Website - http://www.imb.sinica.edu.tw/imbcc/
Contact - Tom, imbcc@imb.sinica.edu.tw, 2789-9195
Description -

Founded in 1988, N105, N106 room located in the first floor of the new building, four work colleagues, the main task is to safeguard this the servers host normal operation, to assist the general information devices within colleagues, poster design and output, network management and information security, and provides consulting and troubleshooting of software and hardware.
Electrophysiology and Calcium Imaging Core Facility

Location - Interdisciplinary Research Building for Science and Technology B2 Floor, I-07
Website - http://www.imb.sinica.edu.tw/core/ecic/
Contact - Huei-Fang Wu, H.F.Wu@imb.sinica.edu.tw, 2789-9343
English Editor

Location - 1th Floor, 111
Website - http://www.imb.sinica.edu.tw/core/editing
Contact - John O'Brien, jobrien@gate.sinica.edu.tw, 2789-9326

Editing On-line Request Form
Fluorescence Activated Cell Sorting Facility （FACS）

Location - 6th Floor, N604
Website - http://www.imb.sinica.edu.tw/core/facs/
Contact - Ya-Min Lin, mbyamin@ccvax.sinica.edu.tw, 2789-9180
Description -

1. Services: Cell Sorting, Multiple Color Data Acquisition and Analysis, Troubleshooting and Data Management
2. Maintenance of FACS Machines: Daily Instrument Quality Control and Laser Alignment
3. Training Courses for FACS User: Principles of FACS, Operation of Flow Cytometer, Data Analysis

Online Booking System
Genomics Core

Location - 1th Floor, N108
Website - Genomics / Mass spectrometry
Contact - Shu-Yun Tung, mbsytung@imb.sinica.edu.tw, 2789-9325

The IMB Genomics Core Facility provides genomics and proteomics relative technologies service to researchers. . We provide Agilent and homemade microarray, two bench-top NGS systems(Roche 454 Junior and Illumina miSeq) at gene expression, regulation and epigenetics studies. We also maintain 3 real-time PCR systems in the core lab.We provides services to all the IMB researchers and their collaborators.
Quantitative PCR Reservation System
Mass Room Reservation System
GC-Q-TOF Service

Location - A721, Agricultural Biotechnology Research Center
Website - http://abrc.sinica.edu.tw/metabolomics/
Contact - Lin, Chih-Yu, zelda@gate.sinica.edu.tw, 2787-2087

The Agilent 7250 GC/Q-TOF system delivers full-spectrum, high-resolution, accurate-mass data with a wide dynamic range for identifying and quantifying GC-amenable compounds. Whether being used in complex metabolomics studies, quadrupole time-of-flight GC/MS provides the ultimate in performance.

Application(*Only for IMB Intranet Network)
Imaging Core

Location - 1th Floor, N104
Website - http://www.imb.sinica.edu.tw/core/imagecore/
Contact - Sue-Ping Lee, spli@gate.sinica.edu.tw, 2789-9190

IMB's Imaging Core Facility is equipped with
-Transmission Electron Microscopy
-Laser Scanning Confocal Microscopy
-Super Resolution Microscopy
-Spinning Disk Microscopy
-DeltaVision Core Imaging System
-Widefield High-Content Analysis System
-Fluorescence Microscopy
-2D and 3D image analysis software
The service items include technical consultation and operational training on EM sample preparation, various types of imaging system operation training and image analysis consulting. Except for EM, all the apparatuses are available all days.

Online Booking System

Institutional Animal Care & Utilization Committee

Location - 6th Floor
Website - http://iacuc.sinica.edu.tw
Contact - Fu-Hwa Liu, iacuc@gate.sinica.edu.tw, 2789-8700

eProtocol 動物實驗線上申請審查系統
Laboratory Safety

Location - 1th Floor, N101
Website - http://www.imb.sinica.edu.tw/core/labsafety/
Contact - Ju-Lan Chao, julan@gate.sinica.edu.tw, 2789-9207
Description -

Job description for the safety office.
1. Radiation protection management
2. Biological laboratory safety management
3. Toxic chemical substances management
4. Controlled anesthetic drugs safety management
5. Laboratory waste disposal management
6. Laboratory personnel health check
7. Promote laboratory safety relevant regulations
8. Film developer management
9. Eenvironmental education for imb staff
Public Instrument Facilities

Location - 1th Floor, N104
Website - http://www.imb.sinica.edu.tw/core/publicfacilities/
Contact - Shu-Mei Huang, freedone@gate.sinica.edu.tw, 2789-9190

Instruments:
1. Cryosectioning System
2. Luminescence / Fluorescence Image and Radioisotope Image Analyzer:
- Fluorescent/Radioisotope Image Analyzer
- Luminescence / Fluorescence /White light Image Analyzer
3. Automatic tissue processor for the histology laboratory
RNA Technology Platform and Gene Manipulation Core

Location - 1th Floor, C6 Core Facility, building B, National Biotechnology Research Park (NBRP)
Website - http://rnai.genmed.sinica.edu.tw/
Contact - RNAiCore@gate.sinica.edu.tw, 7750-5800#2189
Transgenic Core Facility

Location - 5th Floor, N512
Website - http://www.imb.sinica.edu.tw/TCF/
Contact - Ching-Yen Tsai, cytsai@imb.sinica.edu.tw, 2789-9312
Description -

Transgenic Core Facility (TCF) of Academia Sinica, Taiwan, was founded in 1998. We provide services for generating gene-modified mouse including transgenic mice (through microinjecting DNA into pronuclei of fertilized embryos) and gene-targeted mice (through gene-targeting experiment using mouse embryonic stem cells, ESCs, and ESCs blastocyst microinjection), cryopreservation of mouse embryos, mouse in-vitro fertilization (IVF) and consultation regarding any above-related services.