We study RNA- and DNA-binding proteins that play key roles in nucleic acids metabolism. The overall goal is to discover the structure-based mechanisms of these proteins in nucleic acids recognition, processing and degradation. Using the main tool of X-ray crystallography, together with biochemical and biophysical approaches, we determine how these proteins function in trimming and degradation of RNA/DNA in diverse ways.
Over expression, mutations and misfolding of most of the proteins that we study are linked to human diseases, ranging from neurodegenerative disorders to autoimmune diseases. Therefore, understanding how these proteins recognize RNA/DNA and participate in nucleic acids metabolism and how they lose their functions may advance our knowledge in RNA/DNA metabolism and pave the way for the prevention and treatment of related diseases.