Faculty : Yang-Yen, Hsin-Fang

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Yang-Yen, Hsin-Fang

Research Fellow, IMB
Email: imbyy@gate.sinica.edu.tw, Phone: 886-2-2789-9976
Lab: 534, IMB.    Website: http://www.imb.sinica.edu.tw/~imbyy/

Cell Growth and Metabolic Controls in the Mammalian System

Our research interests are to study mammalian cell growth and metabolic controls with emphasis on studying gene functions and signaling closely linked to human diseases such as tumors and metabolic disorders. Experimental systems include using gene disruption/mutation mouse models, mammalian primary and/or established cell line models, as well as using cell-free biochemical analyses. Below are our current research directions:

1. To study the function network of genes involved in the liver cancer development by global gene expression analysis of tumor-prone mouse models.

2. To study the functional cross-talks between lipid metabolism and cell growth controls

3. To study the protein synthesis control in immune cells during activation process.

Selected Recent Publications:

  1. Wu, P.-S., Yang. C.-Y., Yen, J. J.-Y., Chou, C.-H., Chen, SH, Wang, C.-K. Leo, Lai, Y.-G., Liao, N.-S., and Yang-Yen, H.-F*. 2009. Critical roles of TCTP in the homeostasis and T cell receptor-mediated proliferation of peripheral T cells. Journal of Immunology. 183(4):2373-2381. (Epub Jul 15, 2009).
  2. Huang, C.-R., and Yang-Yen, H.-F*. 2010. The fast-mobility isoform of mouse Mcl-1 is a mitochondrial matrix-localized protein with attenuated anti-apoptotic activity. FEBS Letters. 584 (15):3323-3330. [Epub Jul 11, 2010].
  3. Weng, S.-Y., Yang, C.-Y., Li, C.-C., Sun, T.-P., Tung, S.-Y., Yen, J. J.-Y., Tsai, T.-F., Chen, C.-M., Chen, S.-H., Hsiao, M., Huang, P.-H., and Yang-Yen, H.-F*. 2011. Synergism between p53 and Mcl-1 in protecting from hepatic injury, fibrosis and cancer. Journal of Hepatology. 54: 685–694. [Epub Sep 22, 2010] ( doi:10.1016/j.jhep.2010.07.035).
  4. Yang-Yen, H.-F*. 2011. Does N-terminal processing of Mcl-1 occur at mitochondrial outer membrane or matrix? Journal of Biological Chemistry. 286 (30): le15, July 29. (doi:10.1014/jbc.L111.218321) (eLetter)
  5. Chen, P.-H., Chien, F.-C., Lee, S.-P., Chan, W.-E., Lin, I.-H., Liu, C.-S., Lee, F.-J., Lai, J.-S., Chen, P., Yang-Yen, H.-F*., and Yen, J.J.-Y*. 2012. Identification of a novel function of the clathrin-coated structure at the plasma membrane in facilitating GM-CSF receptor-mediated activation of JAK2. Cell Cycle. 11:19, 3611-3626. [Epub Aug 30, 2012] (co-corresponding)
  6. Chiang, Y.-J., Ho, K.-C., Sun, C.-T., Chiu, J.-J., Lee, F.-J., Liao, F., Yang-Yen, H.-F., and Yen, J.J.-Y*.2013. CBAP Functions as a Novel Component in Chemokine-1 induced ZAP70-mediated T-cell Adhesion and Migration. PLoS ONE 8(4):e61761. doi: 10.1371/journal.pone.0061761.
  7. Lin, K.-R., Li, C.-L., Yen, J. J.-Y.* and Yang-Yen, H.-F*.2013. Constitutive phosphorylation of Gata-1 at Serine26 attenuates the colony-forming activity of erythrocyte-committed progenitors. PLoS ONE 8(5): e64269. doi:10.1371/journal.pone.0064269.
  8. Tsai MJ, Yang-Yen HF, Chiang MK, Wang MJ, Wu SS, Chen SH. 2014. TCTP Is Essential for β-Cell Proliferation and Mass Expansion During Development and β-Cell Adaptation in Response to Insulin Resistance. Endocrinology. Feb;155(2):392-404. doi: 10.1210/en.2013-1663.
  9. Choi SW, Shin HK, Yang-Yen HF, Lee MS, Lee CH, Park SJ, Kim KJ, Lee K, Kim SH. Osteoclastogenic activity of translationally-controlled tumor protein (TCTP) with reciprocal repression of p21. 2014. FEBS Lett. S0014-5793(14)00699-1. doi: 10.1016/j.febslet.2014.09.022.
  10. Ho KC, Chiang YJ, Lai AC, Liao NS, Chang YJ, Yang-Yen HF, Yen JJ. 2014. CBAP promotes thymocyte negative selection by facilitating T-cell receptor proximal signaling. Cell Death Dis. Nov 13;5:e1518. doi: 10.1038/cddis.2014.474.
  11. Lin KR, Yang-Yen HF, Lien HW, Liao WH, Huang CJ, Lin LI, Li CL, and Yen JJY* 2016. Murine tribbles homolog 2 deficiency affects erythroid progenitor development and confers macrocytic anemia on mice. Scientific Reports Aug 23;6:31444. doi: 10.1038/srep31444.
  12. Chen LY, Yang-Yen HF, Tsai CC, Thio CLP, Chuang HL, Yang LT, Shen LF, Song IW, Liu KM, Huang YT, Liu FT, Chang YJ, Chen YT and Yen JJY*. 2016. Protein Palmitoylation by ZDHHC13 Protects Skin against Microbial-Driven Dermatitis. The Journal of Investigative Dermatology. pii: S0022-202X(16)32802-0. doi: 10.1016/j.jid.2016.12.011.