Our laboratory is working on the energy metabolic disorders, obesity and diabetes. These two disorders are becoming prevalent worldwide and casting a great burden on health care system in many industrial countries. Currently, we are focusing on the mechanism underlying the Yo-Yo effect. Yo-Yo effect is the fast weight regain phenomenon occurred frequently in people attempting to loss weight rapidly and thus producing physiological stress to their bodies. Our goal is to understand the underlying mechanism and develop effective therapeutic approaches to suppress weight-regain induced by a rapid weight-loss stress.
At the present, we carry out experiments in nematodes, mice and fat cells. The nematode, C. elegans, is an excellent animal model for anti-stress study. We use it to search for the genetic factors involved in surviving the metabolic stress, such as starvation. We use fat cell culture system to study the response of fat cells when their fat store is deprived. By using genetic manipulation technologies, we have also generated transgenic and gene targeted mouse models for corroborating our findings from nematode and fat cell studies and for therapeutic research.
Our current projects include effect of fat-loss stress on energy metabolism, vitality and lifespan in C. elegans and mice.