My lab investigates the molecular basis of interactions between nematodes and nematode-trapping fungi. Using C.elegans and A.oligospora as a model, we ask how do nematodes sense and respond to their predator and how do nematode-trapping fungi sense and kill their prey. We believe that understanding the molecular mechanisms of these interactions will shed insight into the predator and prey co-evolution. Nematode-trapping fungi can sense the presence of their prey and develop elaborate trapping structures. We found that the nematode pheromones, ascarosides, are part of these signals that induce trap-formation. We think that the wide diversity of different ascarosides produceds by nematodes might be a result of evolutionary arm races between nematodes and nematode-trapping fungi. On the other hand, we use genetic, genomic and imaging approaches to study the behavior and neuronal activities of C.elegans in response to nematode-trapping fungi. We found that A.oligospora produce volatile compounds to attract worms and this attraction is mediated by the olfactory neurons of C.elegans. In the future, we will continue to study the molecular mechanisms of how nematode-trapping fungi trap and kill the worms and characterize other C.elegans behaviors in response to nematode-trapping fungi. In the long term, we hope that our study will facilitate the development of new methods, approaches, and treatments for parasitic nematode infection in plants and animals.