Research News
Disruption of the Nuclear Membrane by Perinuclear Inclusions of Mutant Huntingtin Causes Cell-Cycle Re-entry and Striatal Cell Death in Mouse and Cell Models of Huntington
By Dr. Shen, Che-Kun James - November, 2014 Human Molecular Genetics, pii: ddu574All observations provide a strong correlation between the subcellular location of mHTT, disruption of the nucleus, re-entry into the cell-cycle and eventual neuronal death. Also highlight that the subcellular distribution of mHTT is highly dynamic such the distribution of mHTT observed depends on the stage of the disease being examined.
