Research News
The interleukin-15 system suppresses T cell-mediated autoimmunity by regulating negative selection and nTH17 cell homeostasis in the thymus
By Dr. Liao, Nan-Shih - December, 2014 Journal of AutoimmunityThe interleukin-15 (IL-15) system is important for regulating both innate and adaptive immune responses, however, its role in autoimmune disease remained unclear. Here we found that Il15-/- and Il15ra-/- mice spontaneously developed late-onset autoimmune phenotypes. CD4+ T cells of the knockout mice showed elevated autoreactivity as demonstrated by the induction of lymphocyte infiltration in the lacrimal and salivary glands when transferred into nude mice.
