In our program, student learning takes place in research environment in which students benefit from interaction with researchers who are working at the frontiers of knowledge in their disciplines. Research is vigorous and pioneering and this creates a stimulating environment for study. Our staff are enthusiastic and committed to their subject. The enthusiasm and commitment generates an exciting and vibrant learning community. See them by Research Fields.

Principal Investigators (IMB, Academia Sinica)

Chang, Wen
Molecular mechanism of vaccinia virus entry into mammalian hosts
Cellular defense mechanisms and viral host range genes antagonizing host restriction
Chao, Yu-Chan
Baculovirus gene regulation and protein engineering; pseudotyped influenza virus studies and applications
Chen, Hung-Ta
Mechanisms of Eukaryotic Transcription
Chen, Jun-An
Non-coding RNA Function during Motor Neuron Development, Degeneration, and Regeneratio
Chen, Liuh-Yow
Telomere Biology and Telomere Diseases
Chen, Sheng-hong
Lab for Cell Dynamics aims to quantify and model dynamics of signaling networks in single cells as the basis to control cellular behavior for therapeutic purposes

Cheng, Pei-Lin


Mechanisms of neuronal polarization and regeneration

Cheng, Soo-Chen
Molecular mechanism of pre-mRNA splicing
Chien, Cheng-Ting
Dendrite arborization in development and diseases
Synapse formation and plasticity
Chung, Bon-chu
Steroid Regulation, Zebrafish Development, Disease Model, Gene Regulation
Chuang, Huai-hu
Receptor and Channel Function
Hsia, Kuo-Chiang
Molecular and structural basis of cell division
Hsiao, Chwan-Deng (David)
Structural and functional study of protein-DNA and protein-protein interaction by X-ray crystallography
Hsueh, Yen-Ping
Interactions between Nematodes and Nematode-trapping Fungi
Hsueh, Yi-Ping
Neuronal Morphogenesis
Neurodevelopmental disorders
King, Chih-Yen
Molecular biology of amyloid and prions
Structural principle of amyloids
Leu, Jun-Yi
Yeast genomics and experimental evolution
Cell-cell communication and gene network regulation
Genetic and noise buffering
Li, Hsou-min
Protein sorting within cells
Developmental regulation of protein trafficking
Liao, Nan-Shih
Intestine mucosal immunity
Anti-cancer immunity and immunotherapy
Lin-Chao, Sue
Signal pathways govern the control of bacterial RNA degradation;
Function of RNA degradosome components
Function of growth-arrest genes during mouse brain development
RNA biology
Lin, Chien-Ling
Genome-Wide Analysis of the mRNA Splicing and Translation
Lin, Suewei
Molecular and neural mechanisms of motivation and memory
Tsay, Yi-Fang
Molecular mechanism of Nitrate signaling and transport
Wang, Ting-Fang
Chromosome biology and fungal sexual development
Wei, Jen-Hsuan
Cytoskeleton and Organelle Biology
Mechanism of microtubule nucleation: r-TuRC assembly, targeting, and function in neuronal development
Wu, Huey-Nan
The molecular mechanism of flavivirus RNA replication:
the role of viral RNA elements and virus nonstructural protein interactions
Yao, Meng-Chao
Gene amplification, deletion and rearrangements in eukaryotic cells
The role of dsRNA in gene silencing, heterochromatin formation and DNA rearrangements
Yu, Su-May
Mechanisms of nutrient and O2 deficiency signaling in rice
Mechanisms of stress regulation of root development in rice
Yuan, Hanna
Structural and functional studies of DNA and RNA metabolism


Principal Investigators (IBC, Academia Sinica)

  Huang, Fu
Epigenetics, Protein post-translational modification, Transcriptional regulation
Shih, Yu-Ling
Metabolic regulation of cell growth and division in E.coli
Mechanism of bacterial cell wall synthesis
Yao, Chi-Kuang
Mechanism of synaptic transmission and neurodegenerative diseases


Principal Investigators (ICOB, Academia Sinica)

  Chou, Shen-Ju
Neural development, Developmental biology
Chou, Ya-Hui
Developmental Neurobiology, Neuronal circuitry, Insect Behavior
  Fu, Chi-yu
Cryo-electron microscopy and tomography
Mass spectrometry
Hsu, Hwei-Jan
Developmental Biology, Stem cell Biology
  Kuo, Hung-Chih
Stem Cell Biology
Molecular Embryology


Principal Investigators (IPMB, Academia Sinica)

Kuo, Chih-Horng
Utilize genomic, metagenomics, and bioinformatics tools to investigate microbial genome evolution and the diversity


Principal Investigators (GRC, Academia Sinica)

  Chang, Tien-Hsien
Genome-wide bypass of essential genes
Genome architecture
Molecular mechanism of pre-mRNA splicing, mRNA export, and translation
In vivo roles of DExD/H-box proteins in RNA metabolism
Chen, Yun-Ru
Protein misfolding and neurodegenerative diseases
Hwang-Verslues, Wendy W.
Long term goals of the Hwang-Verslues laboratory are to decipher the links among circadian rhythm, core clock gene functions and stem cell (SC) fate/characteristics in tissue development and disease progression
  Juan, Li-Jung
Epigenetic Regulation in Development and Disease
  Lin, Kuo-I
the regulatory mechanisms in immune cell development and function
Lu, Joyce Jean
Efficiently reprogram somatic cell /stem cell fate by high throughput functional screens


Professors (NDMC)

Chen, Chien-Fu F.
Neurobiology of mammalian olfactory system
Hsieh, Po-Shiuan
The casual relationship between inflammation and obesity-associated metabolic syndrome and diabetes mellitus ; The therapeutic approach to prevent and treat metabolic syndrome and type II diabetes
  Huang, Shih-Ming
Nuclear receptor coactivator functions
  Lin, Ya-Wen
  Shiau, Chia-Yang
Pseudohypoxia function of hypoxia inducible factors implicated in stemness, tumorigenesis, and inflammation.
Annexin based chimera as therapeutic and diagnostic tool; Non-ribosomal peptide synthetase (ACV synthetase and Gramicidin S synthetase)
To study regulatory function of chromatin locus around disease associated SNP and their implicated protein factors and epigenetic pattern, especially methyl histone
  Shieh, Yi-­Shing
1. Cancer biology and tumor microenvironment
2. Signal transduction and epigeneticregulation
3. Molecular pathology
4. Head and Neck Oncology
  Wang, Lan-Hsin
Molecular and genetic mechanism of the Hippo pathway in development and disease
  Wu, Chin-Chen
Mechanisms and possible therapies of sepsis associated with septic shock, disseminated intravascular coagulation, or multiple organ failure
  Wu, Gwo-Jang
Cellular and Molecular Mechanisms of Fertilization ; Gametogenesis and Embryo Implantation in Mammals
  Yang, Sung-Sen
Human inherited channelopathy and blood pressure regulation
Genetic Engineering