|[ Dr. Cheng-Ting Chien ] - November, 2014
The COP9 Signalosome Converts Temporal Hormone Signaling to Spatial Restriction on Neural Competence
PLoS Genetics 10(11): e111573. DOI: 10.1371/journal.pgen.1004760
|[ Dr. Chwan-Deng Hsiao ] - November, 2014
Structural and Functional Characterization of Ybr137wp Implicates Its Involvement in the Targeting of Tail-Anchored Proteins to Membranes
Mol. Cell. Biol. 2014, 34(24):4500. DOI:10.1128/MCB.00697-14.
|[ Dr. Y. Henry Sun ] - October, 2014
Carrier of Wingless (Cow), a Secreted Heparan Sulfate Proteoglycan, Promotes Extracellular Transport of Wingless
PLoS ONE 9(10): e111573. doi:10.1371/journal.pone.0111573
|[ Dr. Yi-Ping Hsueh ] - October, 2014
Calcium influx and postsynaptic proteins coordinate the dendritic filopodium-spine transition
Developmental Neurobiology 74:1011-1029
|[ Dr. Yi-Ping Hsueh ] - September, 2014
Neuronal excitation upregulatesTbr1, a high-confidence risk gene of autism, mediating Grin2bexpression in the adult brain
Front Cell Neurosci. 2014 Sep 10;8:280.
|[ Dr. Jun-Yi Leu ] - October, 2014
On the Nature and Evolutionary Impact of Phenotypic Robustness Mechanisms
Annu. Rev. Ecol. Evol. Syst. 45: 495-517 (2014).
|[ Dr. Jun-Yi Leu ] - October, 2014
The Hsp90-dependent proteome is conserved and enriched for hub proteins with high levels of protein-protein connectivity.
Genome Biol. Evol. 6: 2851-2865 (2014)
|[ Dr. Hanna Yuan ] - October, 2014
Structure and function of TatD exonuclease in DNA repair
Nucleic Acids Res. doi: 10.1093/nar/gku732
|[ Dr. Yu-Chan Chao ] - November, 2014
Identification of a high efficiency baculovirus DNA replication origin that functions in insect and mammalian cells
Journal of Virology, 88:13073-85. (Selected as a Spotlight paper)
|[Dr. Nan-Shih Liao ] - August, 2014
Adipocyte IL-15 Regulates Local and Systemic NK Cell Development
The Journal of Immunology. vol. 193 no.4 1747-1758
|[ Dr. Yi-Ping Hsueh ] - August, 2014
Cortactin binding protein 2 increases microtubule stability and regulates dendritic arborization
J Cell Sci. 2014 Aug 15;127:3521-34.
|[ Dr. Su-May Yu ] - April, 2014
SnRK1A-Interacting Negative Regulators Modulate the Nutrient Starvation Signaling Sensor SnRK1 in Source-Sink Communication in Cereal Seedlings under Abiotic Stress
Plant Cell, Vol. 26: 808–827
|[ Dr. Yi-Fang Tsay ] - March, 2014
Plant science: How to switch affinity
Nature 507, 44–45 (06 March 2014) doi:10.1038/nature13063
|[ Dr. Hanna S. Yuan ] - March, 2014
Structural Insights Into DNA Repair by RNase T—An Exonuclease Processing 3' End of Structured DNA in Repair Pathways
PLoS Biol 12(3): e1001803. doi:10.1371/journal.pbio.1001803
|[ Dr. Bon-chu Chung ] - February, 2014
Tumor Necrosis Factor Suppresses NR5A2 Activity and Intestinal Glucocorticoid Synthesis to Sustain Chronic Colitis
Sci. Signal., 7 (314), ra20, 1-11 [DOI: 10.1126/scisignal.2004786] (2014).
|[ Dr. Yi-Ping Hsueh ] - January, 2014
Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality
Nature Neuroscience (2014) doi:10.1038/nn.3626
|[ Dr. Wen Chang ] - January, 2014
Vaccinia Viral Protein A27 is Anchored to the Viral Membrane via a Cooperative Interaction with Viral Membrane Protein A17
J. Biol. Chem. published online January 22, 2014
|[ Dr. Ting-Fang Wang ] - December, 2013
Interorganelle interactions and inheritance patterns of nuclei and vacuoles in budding yeast meiosis
Autophagy. 2013 Dec 4;10(2)
|[ Dr. Bon-chu Chung ] - December, 2013
Mis-regulated Progesterone Secretion and Impaired Pregnancy in Cyp11a1 Transgenic Mice
Biol Reprod, 89 (4) 91, 1-10 (2013). (Recommended by Faculty of 1000 Prime)
|[ Dr. Jun-An Chen ] - December, 2013
An Lmx1b-miR135a2 Regulatory Circuit Modulates Wnt1/Wnt Signaling and Determines the Size of the Midbrain Dopaminergic Progenitor Pool
PLoS Genet 9(12): e1003973. doi:10.1371/journal.pgen.1003973
|[ Dr. Yi-Ping Hsueh ] - December, 2013
Sarm1, a neuronal inflammatory regulator, controls social interaction, associative memory and cognitive flexibility in mice
Brain Behav Immun. 2013 Dec 6. pii: S0889-1591(13)00587-4. doi: 10.1016/j.bbi.2013.12.002.
|[ Dr. Yi-Fang Tsay ] - November, 2013
Two Phloem Nitrate Transporters, NRT1.11 and NRT1.12, Are Important for Redistributing Xylem-Borne Nitrate to Enhance Plant Growth
Plant Physiology, October 2013, vol. 163, 844-856
|[ Dr. Bon-chu Chung ] - September, 2013
Pregnenolone activates CLIP-170 to promote microtubule growth and cell migration
Nature Chem Biol, 9, 636-642 (2013)
|[ Dr. Wen Chang ] - August, 2013
Crystal Structure of Vaccinia Viral A27 Protein Reveals a Novel Structure Critical for Its Function and Complex Formation with A26 Protein.
PLoS Pathog 9(8): e1003563. doi:10.1371/journal.ppat.1003563
|[ Dr. Nan-Shih Liao ] - August, 2013
IL-15 modulates the balance between Bcl-2 and Bim via Jak3/1-PI3K-Akt-ERK pathway to promote CD8αα+ intestinal intraepithelial lymphocyte survival
Eur. J. Immunol. 2013. 00: 1–12.
|[ Dr. Ting-Fang Wang ] - August, 2013
Three Distinct Modes of Mec1/ATR and Tel1/ATM Activation Illustrate Differential Checkpoint Targeting during Budding Yeast Early Meiosis
Mol Cell Biol. 2013 Aug;33(16):3365-76.
|[ Dr. Hsou-min Li ] - August, 2012
Evolution of Chloroplast J Proteins
PLoS One. 2013 Jul 23;8(7):e70384. doi: 10.1371/journal.pone.0070384. Print 2013
|[ Dr. Yi-Ping Hsueh ] - July, 2013
TLR7 Negatively Regulates Dendrite Outgrowth through the Myd88–c-Fos–IL-6 Pathway
Journal of Neuroscience 33:11479-11493
|[ Dr. Hsou-min Li & Dr. Chwan-Deng Hsiao ] - July, 2013
Structural characterizations of the chloroplast translocon protein Tic110
The Plant Journal (2013) doi: 10.1111/tpj.12249
|[ Dr. Hsou-min Li ] - July, 2013
Transit peptide design and plastid import regulation
Trends in Plant Science, Vol. 18, 360-366, 20 May 2013
|[ Dr. Hanna Yuan ] - May, 2013
The Truncated C-terminal RNA Recognition Motif of TDP-43 Protein Plays a Key Role in Forming Proteinaceous Aggregates
J. Biol. Chem. 2013, 288, 9049–9057.
|[ Dr. Sue Lin-Chao ] - April, 2013
Sodium vanadate combined with L-ascorbic acid delays disease progression, enhances motor performance, and ameliorates muscle atrophy and weakness in mice with spinal muscular atrophy
BMC Med. 2013 Feb 14;11(1):38
|[ Dr. Sue Lin-Chao ] - April, 2013
Decreased stathmin expression ameliorates neuromuscular defects but fails to prolong survival in a mouse model of spinal muscular atrophy
Neurobiol Dis. 2013 Apr;52:94-103. doi: 10.1016/j.nbd.2012.11.015.
|[ Dr. Jun-Yi Leu ] - April, 2013
Hsp90 regulates non-genetic variation in response to environmental stress
Molecular Cell 50: 82-92 (2013)
|[ Dr. Bon-chu Chung ] - February, 2013
Steroidogenic Factor 1 (NR5A1) Maintains Centrosome Homeostasis in Steroidogenic Cells by Restricting Centrosomal DNA-Dependent Protein Kinase Activation
Mol Cell Biol. 2013 Feb;33(3):476-84.
|[ Dr. Sue Lin-Chao ] - January, 2013
The Spinal Muscular Atrophy Disease Protein SMN Is Linked to the Golgi Network
PLoS One. 2012;7(12):e51826. doi: 10.1371/journal.pone.0051826. Epub 2012 Dec 17.
|[ Dr. Jun-Yi Leu ] - January, 2013
Dynamic large-scale chromosomal rearrangements fuel rapid evolution in yeast populations
PLoS Genet. 9(1): e1003232 (2013)
|[ Dr. Cheng-Ting Chien ] - November, 2012
Neurofibromin Mediates FAK Signaling in Confining Synapse Growth at Drosophila Neuromuscular Junctions
The Journal of Neuroscience, 21 November 2012, 32(47): 16971-16981; doi: 10.1523/JNEUROSCI.1756-12.2012
|[ Dr. Yi-Ping Hsueh ] - November, 2012
CTTNBP2, but not CTTNBP2NL, regulates dendritic spinogenesis and synaptic distribution of the striatin-PP2A complex
Molecular Biology of the Cell 23:4383-4392.
|[ Dr. Cheng-Ting Chien ] - October, 2012
Activity-dependent retrograde laminin A signaling regulates synapse growth at Drosophila neuromuscular junctions
PNAS October 23, 2012 vol. 109 no. 43 17699-17704
|[ Dr. Hsou-min Li ] - October, 2012
Differential Age-Dependent Import Regulation by Signal Peptides
PLoS Biol 10(10): e1001416. doi:10.1371/journal.pbio.1001416
|[ Dr. Ting-Fang Wang ] - October, 2012
Mek1 stabilizes Hop1-Thr318 phosphorylation to promote interhomolog recombination and checkpoint responses during yeast meiosis Nucleic Acids Research (NAR)
|[ Dr. Su-May Yu ] - October, 2012
Convergent Starvation Signals and Hormone Crosstalk in Regulating Nutrient Mobilization upon Germination in Cereals The Plant Cell, Vol. 24: 2857–2873
|[ Dr. Y. Henry Sun ] - August, 2012
Segregation of eye and antenna fates maintained by mutual antagonism in Drosophila. Development 139, 3413-3421 (2012)
|[ Dr. Jun-Yi Leu ] - July, 2012
The evolution of low mutation rates in experimental mutator populations of Saccharomyces cerevisiae. Curr. Biol. 22: 1235-1240 (2012).
|[ Dr. Yu-Chan Chao ] - July, 2012
A novel exo-cellulase fromwhite spotted longhorn beetle (Anoplophora malasiaca) Insect Biochemistry and Molecular Biology (2012)
|[ Dr. Sue Lin-Chao ] - June, 2012
Gas7-Deficient Mouse Reveals Roles in Motor Function and Muscle Fiber Composition during Aging PLoS ONE 7(5): e37702. doi:10.1371/journal.pone.0037702
|[ Dr. Wen Chang ] - June, 2012
Integrin β1 Mediates Vaccinia Virus Entry through Activation of PI3K/Akt Signaling Journal of Virology 86(12): 6677-6687. (Spotlights in the current issue)
|[ Dr. Michael M. C. Lai ] - April, 2012
Annexin A2 is involved in the formation of hepatitis C virus replication complex on the lipid raft. J Virol. 2012 Apr;86(8):4139-50.
|[ Dr. Sue Lin-Chao ] - April, 2012
Membrane binding of Escherichia coli RNase E catalytic domain stabilizes protein structure and increases RNA substrate affinity. PNAS, 2012
|[ Dr. John Yu ] - March, 2012
Cancer-initiating Cells in KrasG12D-induced lung Adenocarcinoma. Cancer Research 71:7250 2011
|[ Dr. John Yu ] - March, 2012
Changes in Glycosphingolipid Composition During Differentiation of Human Embryonic Stem Cells to Ectodermal or Endodermal Lineages. STEM CELLS 2011;29:1995–2004
|[ Dr. Hsou-min Li ] - April, 2012
The amino-terminal domain of chloroplast Hsp93 is important for its membrane association and functions in vivo. Plant Physiology 158:1656-1665, 2012
|[ Dr. Wen Chang ] - April, 2012
The Lipid Raft-Associated Protein CD98 Is Required for Vaccinia Virus Endocytosis. Journal of Virology 86(9):4868,2012 (Spotlights in the current issue)
|[ Dr. Jun-Yi Leu ] - April, 2012
The histone deacetylase Hos2 forms an Hsp42-dependent cytoplasmic granule in quiescent yeast cells. Mol. Biol. Cell 23(7): 1231-1242 (2012)
|[ Dr. Wen Chang ] - March, 2012
Vaccinia Mature Virus Fusion Regulator A26 Protein Binds to A16 and G9 Proteins of the Viral Entry Fusion Complex and Dissociates from Mature Virions at Low pH. J. Virol. 2012, 86(7):3809-3818.
|[ Dr. Yi-Ping Hsueh ] - Jan, 2012
Cortactin-Binding Protein 2 Modulates the Mobility of Cortactin and Regulates Dendritic Spine Formation and Maintenance Journal of Neuroscience 2012 32:1043-1055 (highlighted by cover image and "This week in the Journal")
|[ Dr. Michael M.C. Lai ] - Feb, 2012
PSTPIP2, proline-serine-threonine phosphatase interacting protein 2, a host membrane-deforming protein, is critical for membranous web formation in Hepatitis C Virus replication. J. Virol. 86(3): 1739-1749.
|[ Dr. John Yu ] - January, 2012
Researchers Find Cancer-initiating Cells in KrasG12D-induced lung Adenocarcinoma. Cancer Res December 1, 2011 71; 7250
|[ Dr. Yi-Ping Hsueh ] - November, 2011
Valosin-containing protein and neurofibromin interact to regulate dendritic spine density Journal of Clinical Investigation doi:10.1172/JCI45677
|[ Dr. Cheng-Ting Chien ] - October, 2011
Nak regulates localization of clathrin sites in higher-order dendrites to promote local dendrite growth. Neuron. 72(2) 285-299.
[ Video Abstract ]
|[ Dr. Michael M.C. Lai ] - Sep, 2011
Rab5 and Class III Phosphoinositide 3-Kinase Vps34 Are Involved in Hepatitis C Virus NS4B-Induced Autophagy J Virol. 2011, 85:10561-71.
|[ Dr. Yu-Chan Chao ] - August, 2011
A Non-coding RNA of Insect HzNV-1 Virus Establishes Latent Viral Infection through MicroRNA Scientific Reports. (New journal form Nature publishing group). 2011.1. Article number: 60.
|[ Dr. Nan-Shih Liao ] - August, 2011
IL-15Rα of Radiation-Resistant Cells is Necessary and Sufficient for Thymic Invariant NKT Cell Survival and Functional Maturation J Immunol 2011;187;1235-1242.
|[ Dr. Nan-Shih Liao ] - July, 2011
Different NK cell developmental events require different levels of IL-15 trans-presentation J Immunol 187, 1212-1221.
|[ Dr. Yu-Chan Chao ] - July, 2011
Heliothis zea Nudivirus 1 Gene hhi1 Induces Apoptosis Which Is Blocked by the Hz-iap2 Gene and a Noncoding Gene, pag1 The Journal of Virology, July 2011,p. 6856-6866, Vol. 85, No. 14
|[ Dr. Michael M.C. Lai ] - July, 2011
The SUMOylation of Matrix Protein M1 Modulates the Assembly and Morphogenesis of Influenza A Virus J Virol. 85(13):6618-28. Epub 2011 Apr 20.
|[ Dr. Yi-Fang Tsay ] - July, 2011
Arabidopsis Nitrate Transporter NRT1.9 Is Important in Phloem Nitrate Transport Plant Cell 23: 1945-1957. 2011.
|[ Dr. Wen Chang ] - June, 2011
Synthesis of 3-O-sulfonated heparan sulfate octasaccharides that inhibit the herpes simplex virus type 1 host–cell interaction Nature Chemistry 3,557–563 (2011)
|[ Dr. Jun-Yi Leu ] - June, 2011
Clusters of Nucleotide Substitutions and Insertion/Deletion Mutations Are Associated with Repeat Sequences PLoS Biol. 9(6): e1000622 (2011)
|[ Dr. Yi-Ping Hsueh ] - May, 2011
Sarm1, a negative regulator of Toll-like receptor 3 signaling, interacts with syndecan-2 and regulates neuronal morphology Journal of Cell Biology 193:769-784 (2011)
|[ Dr. Yi-Fang Tsay ] - April, 2011
Integration of Nitrogen and Potassium Signaling Annu. Rev. Plant Biol. 62: 207-226 (2011)
|[ Dr. Jun-Yi Leu ] - March, 2011
A Tradeoff Drives the Evolution of Reduced Metal Resistance in Natural Populations of Yeast PLoS Genet. 7(3): e1002034 (2011)
|[ Dr. Hanna Yuan ] - March, 2011
Structural basis for RNA trimming by RN ase T in stable RNA 3′-end maturation Nature Chem. Biol. 7, 236-243 (2011)
|[ Dr. Ting-Fang Wang ] - March, 2011
Genetic Requirements and Meiotic Function of Phosphorylation of the Yeast Axial Element Protein Red1 Mol. Cell. Biol. (2011) 31, 912-923
|[ Dr. Cheng-Ting Chien ] - February, 2011
CSN-mediated deneddylation differentially modulates Ci155 proteolysis to promote Hedgehog signalling responses
Nature Communications, doi:10.1038/ncomms1185
|[ Dr. Hsou-min Li ] - November, 2010
Pea chloroplast DnaJ-J8 and Toc12 are encoded by the same gene and localized in the stroma Plant Physiology 154:1172-1182, 2010
|[ Dr. Michael M. C. Lai ] - November, 2010
Ubiquitination and deubiquitination of NP protein regulates influenza A virus RNA replication EMBO J. 2010 Oct 5.
|[ Dr. Michael M. C. Lai ] - November, 2010
Hepatitis C virus egress and release depend on endosomal trafficking of core
|[ Dr. Cheng-Ting Chien ] - September, 2010
LRRK2 G2019S Mutation Induces Dendrite Degeneration through Mislocalization and Phosphorylation of Tau by Recruiting Autoactivated GSK3β The Journal of Neuroscience, 2010, 30(39): 13138-13149
|[ Dr. Wen Chang ] - August, 2010
Vaccinia Virus A25 and A26 Proteins Are Fusion Suppressors for Mature Virions and Determine Strain-Specific Virus Entry Pathways into HeLa, CHO-K1, and L Cells (2010), J. Virol. 84: 8422-8432.
|[Dr. Jun-Yi Leu ] - July, 2010
Multiple Molecular Mechanisms Cause Reproductive Isolation between Three Yeast Species. PLoS Biol. 8(7): e1000432 (2010).
|[Dr. Su-May Yu ] - July, 2010
A Novel MYBS3-Dependent Pathway Confers Cold Tolerance in Rice. Plant Physiology 153:145-158 (2010)
|[Dr. Hsou-min Li ] - July, 2010
Stromal Hsp70 Is Important for Protein Translocation into Pea and Arabidopsis Chloroplasts. Plant Cell 22: 1516-1531, 2010
|[Dr. Hsou-min Li ] - May, 2010
Protein Transport into Chloroplasts. Annu. Rev. Plant Biol. 61: 157-180, 2010
|[Dr. Yu-Chan Chao ] - May, 2010
Autographa californica Multiple Nucleopolyhedrovirus LEF-2 Is a Capsid Protein Required for Amplification but Not Initiation of Viral DNA Replication J Virol. 2010 May;84(10):5015-24
|[Dr. Sue Lin-Chao ] - April, 2010
Gas7 Functions with N-WASP to Regulate the Neurite Outgrowth of Hippocampal Neurons J Biol. Chem. 285, 11652-11666.2010
|[ Dr. Ting-Fang Wang ] - February, 2010
Yeast axial-element protein, Red1, binds SUMO chains to promote meiotic interhomologue recombination and chromosome synapsis. EMBO Journal 29, 586-596.
|[ Dr. Yu-Chan Chao ] - December, 2009
The Early Gene hhi1 Reactivates Heliothis zea Nudivirus 1 in Latently Infected Cells. J Virol. 84: 1057-1065.
|[ Dr. Su-May Yu ] - October, 2009
Coordinated Responses to Oxygen and Sugar Deficiency Allows Rice Seedlings to Tolerate Flooding. Sci. Signal., Vol. 2, Issue 91, p. ra61
|[Dr. Yi-Fang Tsay ] - September, 2009
CHL1 functions as a nitrate sensor in plants. Cell 138, 1184~1194
|Dr. Wen Chang ] - July, 2009
Disulfide Bond Formation at the C Termini of Vaccinia Virus A26 and A27 Proteins Does Not Require Viral Redox Enzymes and Suppresses Glycosaminoglycan-Mediated Cell Fusion J. Virol 83:6464-6476,2009
|[Dr. Yu-Chan Chao ] - April, 2009
RING and Coiled-Coil Domains of Baculovirus IE2 Are Critical in Strong Activation of the Cytomegalovirus Major Immediate-Early Promoter in Mammalian Cells Journal of Virology 83 (8) p. 3604-3616.
|[Dr. Cheng-Ting Chien ] - April, 2009
Gcm protein degradation suppresses proliferation of glial progenitors PNAS (USA), Vol106, pp 6778-6783.
|[ Dr. Chwan-Deng Hsiao ] - March, 2009
The crystal structure of a replicative hexameric helicase DnaC and its complex with single-stranded DNA Nucleic Acids Res. 37, 804-814, 2009.
|[Dr. Wen Chang ] - February, 2009
Poxviral host range protein CP77 contains a F-box-like domain that is necessary to suppress NF-kB activation by TNF-α but is independent of its host range function J. Virol. doi:10.1128/JVI.01835-08.
|[ Dr. Sue Lin-Chao ] - January, 2009
Regulation of ribonuclease E activity by the L4 ribosomal protein of Escherichia coli
Proc. Natl. Acad. Sci. USA:864-869, 2009.