Research Spotlight
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| [ Dr. Hanna Yuan ] - May, 2013 The Truncated C-terminal RNA Recognition Motif of TDP-43 Protein Plays a Key Role in Forming Proteinaceous Aggregates J. Biol. Chem. 2013, 288, 9049–9057. |
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| [ Dr. Sue Lin-Chao ] - April, 2013 Sodium vanadate combined with L-ascorbic acid delays disease progression, enhances motor performance, and ameliorates muscle atrophy and weakness in mice with spinal muscular atrophy BMC Med. 2013 Feb 14;11(1):38 |
[ Dr. Sue Lin-Chao ] - April, 2013 Decreased stathmin expression ameliorates neuromuscular defects but fails to prolong survival in a mouse model of spinal muscular atrophy Neurobiol Dis. 2013 Apr;52:94-103. doi: 10.1016/j.nbd.2012.11.015. |
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| [ Dr. Jun-Yi Leu ] - April, 2013 Hsp90 regulates non-genetic variation in response to environmental stress Molecular Cell 50: 82-92 (2013) |
[ Dr. Bon-chu Chung ] - February, 2013 Steroidogenic Factor 1 (NR5A1) Maintains Centrosome Homeostasis in Steroidogenic Cells by Restricting Centrosomal DNA-Dependent Protein Kinase Activation Mol Cell Biol. 2013 Feb;33(3):476-84. |
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| [ Dr. Sue Lin-Chao ] - January, 2013 The Spinal Muscular Atrophy Disease Protein SMN Is Linked to the Golgi Network PLoS One. 2012;7(12):e51826. doi: 10.1371/journal.pone.0051826. Epub 2012 Dec 17. |
[ Dr. Jun-Yi Leu ] - January, 2013 Dynamic large-scale chromosomal rearrangements fuel rapid evolution in yeast populations PLoS Genet. 9(1): e1003232 (2013) |
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| [ Dr. Cheng-Ting Chien ] - November, 2012 Neurofibromin Mediates FAK Signaling in Confining Synapse Growth at Drosophila Neuromuscular Junctions The Journal of Neuroscience, 21 November 2012, 32(47): 16971-16981; doi: 10.1523/JNEUROSCI.1756-12.2012 |
[ Dr. Yi-Ping Hsueh ] - November, 2012 CTTNBP2, but not CTTNBP2NL, regulates dendritic spinogenesis and synaptic distribution of the striatin-PP2A complex Molecular Biology of the Cell 23:4383-4392. |
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| [ Dr. Cheng-Ting Chien ] - October, 2012 Activity-dependent retrograde laminin A signaling regulates synapse growth at Drosophila neuromuscular junctions PNAS October 23, 2012 vol. 109 no. 43 17699-17704 |
[ Dr. Hsou-min Li ] - October, 2012 Differential Age-Dependent Import Regulation by Signal Peptides PLoS Biol 10(10): e1001416. doi:10.1371/journal.pbio.1001416 |
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| [ Dr. Ting-Fang Wang ] - October, 2012 Mek1 stabilizes Hop1-Thr318 phosphorylation to promote interhomolog recombination and checkpoint responses during yeast meiosis Nucleic Acids Research (NAR) |
[ Dr. Su-May Yu ] - October, 2012 Convergent Starvation Signals and Hormone Crosstalk in Regulating Nutrient Mobilization upon Germination in Cereals The Plant Cell, Vol. 24: 2857–2873 |
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| [ Dr. Y. Henry Sun ] - August, 2012 Segregation of eye and antenna fates maintained by mutual antagonism in Drosophila. Development 139, 3413-3421 (2012) |
[ Dr. Jun-Yi Leu ] - July, 2012 The evolution of low mutation rates in experimental mutator populations of Saccharomyces cerevisiae. Curr. Biol. 22: 1235-1240 (2012). |
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| [ Dr. Yu-Chan Chao ] - July, 2012 A novel exo-cellulase fromwhite spotted longhorn beetle (Anoplophora malasiaca) Insect Biochemistry and Molecular Biology (2012) |
[ Dr. Sue Lin-Chao ] - June, 2012 Gas7-Deficient Mouse Reveals Roles in Motor Function and Muscle Fiber Composition during Aging PLoS ONE 7(5): e37702. doi:10.1371/journal.pone.0037702 |
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| [ Dr. Wen Chang ] - June, 2012 Integrin β1 Mediates Vaccinia Virus Entry through Activation of PI3K/Akt Signaling Journal of Virology 86(12): 6677-6687. (Spotlights in the current issue) |
[ Dr. Michael M. C. Lai ] - April, 2012 Annexin A2 is involved in the formation of hepatitis C virus replication complex on the lipid raft. J Virol. 2012 Apr;86(8):4139-50. |
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| [ Dr. Sue Lin-Chao ] - April, 2012 Membrane binding of Escherichia coli RNase E catalytic domain stabilizes protein structure and increases RNA substrate affinity. PNAS, 2012 |
[ Dr. John Yu ] - March, 2012 Cancer-initiating Cells in KrasG12D-induced lung Adenocarcinoma. Cancer Research 71:7250 2011 |
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| [ Dr. John Yu ] - March, 2012 Changes in Glycosphingolipid Composition During Differentiation of Human Embryonic Stem Cells to Ectodermal or Endodermal Lineages. STEM CELLS 2011;29:1995–2004 |
[ Dr. Hsou-min Li ] - April, 2012 The amino-terminal domain of chloroplast Hsp93 is important for its membrane association and functions in vivo. Plant Physiology 158:1656-1665, 2012 |
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| [ Dr. Wen Chang ] - April, 2012 The Lipid Raft-Associated Protein CD98 Is Required for Vaccinia Virus Endocytosis. Journal of Virology 86(9):4868,2012 (Spotlights in the current issue) |
[ Dr. Jun-Yi Leu ] - April, 2012 The histone deacetylase Hos2 forms an Hsp42-dependent cytoplasmic granule in quiescent yeast cells. Mol. Biol. Cell 23(7): 1231-1242 (2012) |
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| [ Dr. Wen Chang ] - March, 2012 Vaccinia Mature Virus Fusion Regulator A26 Protein Binds to A16 and G9 Proteins of the Viral Entry Fusion Complex and Dissociates from Mature Virions at Low pH. J. Virol. 2012, 86(7):3809-3818. |
[ Dr. Yi-Ping Hsueh ] - Jan, 2012 Cortactin-Binding Protein 2 Modulates the Mobility of Cortactin and Regulates Dendritic Spine Formation and Maintenance Journal of Neuroscience 2012 32:1043-1055 (highlighted by cover image and "This week in the Journal") |
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| [ Dr. Michael M.C. Lai ] - Feb, 2012 PSTPIP2, proline-serine-threonine phosphatase interacting protein 2, a host membrane-deforming protein, is critical for membranous web formation in Hepatitis C Virus replication. J. Virol. 86(3): 1739-1749. |
[ Dr. John Yu ] - January, 2012 Researchers Find Cancer-initiating Cells in KrasG12D-induced lung Adenocarcinoma. Cancer Res December 1, 2011 71; 7250 |
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| [ Dr. Yi-Ping Hsueh ] - November, 2011 Valosin-containing protein and neurofibromin interact to regulate dendritic spine density Journal of Clinical Investigation doi:10.1172/JCI45677 |
[ Dr. Cheng-Ting Chien ] - October, 2011 Nak regulates localization of clathrin sites in higher-order dendrites to promote local dendrite growth. Neuron. 72(2) 285-299. [ Video Abstract ] |
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| [ Dr. Michael M.C. Lai ] - Sep, 2011 Rab5 and Class III Phosphoinositide 3-Kinase Vps34 Are Involved in Hepatitis C Virus NS4B-Induced Autophagy J Virol. 2011, 85:10561-71. |
[ Dr. Yu-Chan Chao ] - August, 2011 A Non-coding RNA of Insect HzNV-1 Virus Establishes Latent Viral Infection through MicroRNA Scientific Reports. (New journal form Nature publishing group). 2011.1. Article number: 60. |
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| [ Dr. Nan-Shih Liao ] - August, 2011 IL-15Rα of Radiation-Resistant Cells is Necessary and Sufficient for Thymic Invariant NKT Cell Survival and Functional Maturation J Immunol 2011;187;1235-1242. |
[ Dr. Nan-Shih Liao ] - July, 2011 Different NK cell developmental events require different levels of IL-15 trans-presentation J Immunol 187, 1212-1221. |
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| [ Dr. Yu-Chan Chao ] - July, 2011 Heliothis zea Nudivirus 1 Gene hhi1 Induces Apoptosis Which Is Blocked by the Hz-iap2 Gene and a Noncoding Gene, pag1 The Journal of Virology, July 2011,p. 6856-6866, Vol. 85, No. 14 |
[ Dr. Michael M.C. Lai ] - July, 2011 The SUMOylation of Matrix Protein M1 Modulates the Assembly and Morphogenesis of Influenza A Virus J Virol. 85(13):6618-28. Epub 2011 Apr 20. |
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| [ Dr. Yi-Fang Tsay ] - July, 2011 Arabidopsis Nitrate Transporter NRT1.9 Is Important in Phloem Nitrate Transport Plant Cell 23: 1945-1957. 2011. |
[ Dr. Wen Chang ] - June, 2011 Synthesis of 3-O-sulfonated heparan sulfate octasaccharides that inhibit the herpes simplex virus type 1 host–cell interaction Nature Chemistry 3,557–563 (2011) |
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| [ Dr. Jun-Yi Leu ] - June, 2011 Clusters of Nucleotide Substitutions and Insertion/Deletion Mutations Are Associated with Repeat Sequences PLoS Biol. 9(6): e1000622 (2011) |
[ Dr. Yi-Ping Hsueh ] - May, 2011 Sarm1, a negative regulator of Toll-like receptor 3 signaling, interacts with syndecan-2 and regulates neuronal morphology Journal of Cell Biology 193:769-784 (2011) |
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| [ Dr. Yi-Fang Tsay ] - April, 2011 Integration of Nitrogen and Potassium Signaling Annu. Rev. Plant Biol. 62: 207-226 (2011) |
[ Dr. Jun-Yi Leu ] - March, 2011 A Tradeoff Drives the Evolution of Reduced Metal Resistance in Natural Populations of Yeast PLoS Genet. 7(3): e1002034 (2011) |
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| [ Dr. Hanna Yuan ] - March, 2011 Structural basis for RNA trimming by RN ase T in stable RNA 3′-end maturation Nature Chem. Biol. 7, 236-243 (2011) |
[ Dr. Ting-Fang Wang ] - March, 2011 Genetic Requirements and Meiotic Function of Phosphorylation of the Yeast Axial Element Protein Red1 Mol. Cell. Biol. (2011) 31, 912-923 |
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| [ Dr. Cheng-Ting Chien ] - February, 2011 CSN-mediated deneddylation differentially modulates Ci155 proteolysis to promote Hedgehog signalling responses Nature Communications, doi:10.1038/ncomms1185 |
[ Dr. Hsou-min Li ] - November, 2010 Pea chloroplast DnaJ-J8 and Toc12 are encoded by the same gene and localized in the stroma Plant Physiology 154:1172-1182, 2010 |
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| [ Dr. Michael M. C. Lai ] - November, 2010 Ubiquitination and deubiquitination of NP protein regulates influenza A virus RNA replication EMBO J. 2010 Oct 5. |
[ Dr. Michael M. C. Lai ] - November, 2010 Hepatitis C virus egress and release depend on endosomal trafficking of core |
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| [ Dr. Cheng-Ting Chien ] - September, 2010 LRRK2 G2019S Mutation Induces Dendrite Degeneration through Mislocalization and Phosphorylation of Tau by Recruiting Autoactivated GSK3β The Journal of Neuroscience, 2010, 30(39): 13138-13149 |
[ Dr. Wen Chang ] - August, 2010 Vaccinia Virus A25 and A26 Proteins Are Fusion Suppressors for Mature Virions and Determine Strain-Specific Virus Entry Pathways into HeLa, CHO-K1, and L Cells (2010), J. Virol. 84: 8422-8432. |
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| [Dr. Jun-Yi Leu ] - July, 2010 Multiple Molecular Mechanisms Cause Reproductive Isolation between Three Yeast Species. PLoS Biol. 8(7): e1000432 (2010). |
[Dr. Su-May Yu ] - July, 2010 A Novel MYBS3-Dependent Pathway Confers Cold Tolerance in Rice. Plant Physiology 153:145-158 (2010) |
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| [Dr. Hsou-min Li ] - July, 2010 Stromal Hsp70 Is Important for Protein Translocation into Pea and Arabidopsis Chloroplasts. Plant Cell 22: 1516-1531, 2010 |
[Dr. Hsou-min Li ] - May, 2010 Protein Transport into Chloroplasts. Annu. Rev. Plant Biol. 61: 157-180, 2010 |
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| [Dr. Yu-Chan Chao ] - May, 2010 Autographa californica Multiple Nucleopolyhedrovirus LEF-2 Is a Capsid Protein Required for Amplification but Not Initiation of Viral DNA Replication J Virol. 2010 May;84(10):5015-24 |
[Dr. Sue Lin-Chao ] - April, 2010 Gas7 Functions with N-WASP to Regulate the Neurite Outgrowth of Hippocampal Neurons J Biol. Chem. 285, 11652-11666.2010 |
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| [ Dr. Ting-Fang Wang ] - February, 2010 Yeast axial-element protein, Red1, binds SUMO chains to promote meiotic interhomologue recombination and chromosome synapsis. EMBO Journal 29, 586-596. |
[ Dr. Yu-Chan Chao ] - December, 2009 The Early Gene hhi1 Reactivates Heliothis zea Nudivirus 1 in Latently Infected Cells. J Virol. 84: 1057-1065. |
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| [ Dr. Su-May Yu ] - October, 2009 Coordinated Responses to Oxygen and Sugar Deficiency Allows Rice Seedlings to Tolerate Flooding. Sci. Signal., Vol. 2, Issue 91, p. ra61 |
[Dr. Yi-Fang Tsay ] - September, 2009 CHL1 functions as a nitrate sensor in plants. Cell 138, 1184~1194 |
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| Dr. Wen Chang ] - July, 2009 Disulfide Bond Formation at the C Termini of Vaccinia Virus A26 and A27 Proteins Does Not Require Viral Redox Enzymes and Suppresses Glycosaminoglycan-Mediated Cell Fusion J. Virol 83:6464-6476,2009 |
[Dr. Yu-Chan Chao ] - April, 2009 RING and Coiled-Coil Domains of Baculovirus IE2 Are Critical in Strong Activation of the Cytomegalovirus Major Immediate-Early Promoter in Mammalian Cells Journal of Virology 83 (8) p. 3604-3616. |
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| [Dr. Cheng-Ting Chien ] - April, 2009 Gcm protein degradation suppresses proliferation of glial progenitors PNAS (USA), Vol106, pp 6778-6783.  |
[ Dr. Chwan-Deng Hsiao ] - March, 2009 The crystal structure of a replicative hexameric helicase DnaC and its complex with single-stranded DNA Nucleic Acids Res. 37, 804-814, 2009. |
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| [Dr. Wen Chang ] - February, 2009 Poxviral host range protein CP77 contains a F-box-like domain that is necessary to suppress NF-kB activation by TNF-α but is independent of its host range function J. Virol. doi:10.1128/JVI.01835-08. |
[ Dr. Sue Lin-Chao ] - January, 2009 Regulation of ribonuclease E activity by the L4 ribosomal protein of Escherichia coli Proc. Natl. Acad. Sci. USA:864-869, 2009. |
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| [ Dr. Su-May Yu ] - December, 2008 A Novel Class of Gibberellin 2-Oxidases Control Semidwarfism, Tillering and Root Development in Rice Plant Cell (2008) 20:2603-2618. |
[Dr. Jun-Yi Leu ] - December, 2008 Incompatibility of Nuclear and Mitochondrial Genomes Causes Hybrid Sterility between Two Yeast Species Cell, Volume 135, Issue 6, 1065-1073. |
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| [ Dr. Cheng-Ting Chien ] - October, 2008 Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth Neural Development 2008, 3:26. |
[ Dr. Cheng-Ting Chien ] - October, 2008 DEN1 deneddylates non-cullin proteins in vivo |
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| [Dr. Chih-Yen King ] - September, 2008 Strain-specific sequences required for yeast [PSI+] prion propagation |
[ Dr. Wen Chang ] - August, 2008 Vaccinia viral protein WR53.5/F14.5 is a new component of intracellular mature virus and is important for calcium-independent cell adhesion and vaccinia virus virulence in mice. J. Virol. doi:10.1128/JVI.00816-08 |
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| [ Dr. Henry Sun ] - July, 2008 Temporal switching of regulation and function of eye gone (eyg) in Drosophila eye development. Dev Biol. 2008 Jul 4. |
[ Dr. Yi-Ping Hsueh ] - July, 2008 SUMOylation of the MAGUK protein CASK regulates dendritic spinogenesis Journal of Cell Biology doi:10.1083/jcb.200712094 |
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| [ Dr. Soo-Chen Cheng ] - June, 2008 Both catalytic steps of nuclear pre-mRNA splicing are reversible Science 320, 1782-1784. |
[ Dr. Wen Chang ] - June, 2008 |
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| [ Dr. Bon-chu Chung ] - April, 2008 Mutation of mouse Cyp11a1 promoter caused tissue-specific reduction of gene expression and blunted stress response without affecting reproduction Mol. Endocrinol. 22, 915-923 (2008). |
[ Dr. Su-May Yu ] Fish eye in rice seeds? -- Global functional analyses of rice promoters by genomics approaches Plant Molecular Biology 65:417-425. |
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| [ Dr. Nan-Shih Liao ] - March, 2008 IL-15 does not affect IEL development in the thymus but regulates homeostasis of putative precursor and mature CD8αα+ IELs in the intestine The Journal of Immunology 180: 3757-3765 (2008). |
[ Dr. Soo-Chen Cheng ] - December, 2007 Dynamic interactions of Ntr1-Ntr2 with Prp43 and with U5 govern the recruitment of Prp43 to mediate spliceosome disassembly Mol. Cell. Biol. 27, 8027-8037 (2007). |
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| [ Dr. Su-May Yu ] - November, 2007 The SnRK1A Protein Kinase Plays a Key Role in Sugar Signaling During Germination and Seedling Growth of Rice Plant Cell, 19: 2484-2499 (2007). |
[ Dr. Bon-chu Chung ] - October 2007 Histone deacetylase inhibitors reduce steroidogenesis through SCF-mediated ubiquitination and degradation of Steroidogenic Factor 1 (NR5A1) Mol. Cell. Biol.27, 7284-7290 (2007). |
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| [ Dr. Chwan-Deng Hsiao ] - October, 2007 Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification. Nucleic Acids Research Advance Access published online on October 16, 2007. |
[ Dr. Cheng-Ting Chien ] - August, 2007 Suppression of Hedgehog signaling by Cul3 ligases in proliferation control of retinal precursors Developmental Biology 308(1):106-19. |
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| [ Dr. Soo-Chen Cheng ] - August, 2007 A diagram illustrating the interaction of Yju2 with NTC, with HP, with the Spliceosome and its function in the splicing reaction Mol. Cell. Biol. 27, 5403-5413. 2007. |
[ Dr. Yi-Ping Hsueh ] - June 2007 Syndecan-2 induces filopodia and dendritic spine formation via the neurofibromin–PKA–Ena/VASP pathway Journal of Cell Biology 177:829-841 (2007). |
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| [ Dr. Bon-chu Chung ] - April 2007 AP-1 Cooperates with SF-1 to Regulate cAMP-Dependent Human CYP11A1 Transcription in vitro and in vivo Endocrinol. 148, 1804-1812 (2007). |
[ Dr. Hanna Yuan ] - March 2007 Structural basis for sequence-dependent DNA cleavage by nonspecific endonucleases EMBO J. 26(6), 1660-1669 (2007) |
