Publications

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Selected Publications

  1. Lin, C.-H., Li, H., Lee, Y.-N., Cheng, Y.-J., Wu, R.-M., and Chien, C.-T.* (2015) Lrrk regulates the dynamic profile of dendritic Golgi outposts through the golgin Lava lamp. J. Cell. Biol., 210(3) 471-483. [PDF]
  2. Huang, Y.-C., Lu, Y.-N., Wu, J.-T., Chien, C.-T.* and Pi, H.* (2014) The COP9 Signalosome Converts Temporal Hormone Signaling to Spatial Restriction on Neural Competence. PLoS Genet., 10(11):e1004760. [PDF]
  3. Tsai, P.-I., Wang, M., Kao, H.-H., Cheng, Y.-J., Lin, Y.-J., Chen, R.-H., and Chien, C.-T.* (2012) Activity-dependent retrograde Laminin A signaling regulates synapse growth at Drosophila neuromuscular junctions. Proc Natl Acad Sci USA., 109:17699-17704. [PDF]
  4. Yang, W.-K., Peng, Y.-H., Li, H., Lin, H.-C., Lin, Y.-J., Lai, T.-T., Suo, H., Wang, C.-H. Lin, W.-H., Ou, C.-Y., Zhou, X., Pi, H., Chang, H. C, Chien, C.-T.* (2011) Nak regulates localization of clathrin sites in higher-order dendrites to promote local dendrite growth. Neuron. 72(2) 285-299. [PDF]
  5. Wu, J.-T., Lin W.-H., Chen, W.-Yu., Huang, Y.-C., Tang, C.-Y., Ho, M. S., Pi, H., and Chien, C.-T., * (2011) CSN-mediated deneddylation differentially modulates Ci155 proteolysis to promote Hedgehog signalling responses. Nat. Commun., 2: 182. [PDF]

Publications List

  1. Lin, C.-H., Li, H., Lee, Y.-N., Cheng, Y.-J., Wu, R.-M., and Chien, C.-T.* (2015) Lrrk regulates the dynamic profile of dendritic Golgi outposts through the golgin Lava lamp. J. cell. Biol., 210(3) 471-483.
  2. Huang, Y.-C., Lu, Y.-N., Wu, J.-T., Chien, C.-T. * and Pi, H.-W. * (2014) The COP9 Signalosome Converts Temporal Hormone Signaling to Spatial Restriction on Neural Competence. PLoS Genet. 10(11):e1004760
  3. Wang, C.-H., Chen, G.-C., and Chien, C.-T.* (2014) The deubiquitinase Leon/USP5 regulates ubiquitin homeostasis during Drosophila development. Biochem. Biophys. Res. Commun. 452: 369-375
  4. Tsai, P.-I., Wang, M., Kao, H.-H., Chen, Y.-J., Lin, Y.-J., Chen, R.-H., and Chien, C.-T.* (2012) Activity-dependent retrograde Laminin A signaling regulates synapse growth at Drosophila neuromuscular junctions. Proc Natl Acad Sci USA., 109:17699-17704
  5. Tsai, P.-I., Wang, M., Kao, H.-H., Chen, Y.-J., Walker, J. A., Chen, R.-H., and Chien, C.-T.* (2012) Neurofibromin mediates FAK signaling in confining synapse growth at Drosophila neuromuscular junctions. J Neurosci., 32:16971-16981 
  6. Yang, W.-K., Peng, Y.-H., Li, H., Lin, H.-C., Lin, Y.-J., Lai, T.-T., Suo, H., Wang, C.-H. Lin, W.-H., Ou, C.-Y., Zhou, X., Pi, H., Chang, H. C, Chien, C.-T.* (2011) Nak regulates localization of clathrin sites in higher-order dendrites to promote local dendrite growth. Neuron. 72(2) 285-299.
  7. Lin, C.-H., Tsai, P.-I, Wu, R.-M. and Chien, C.-T.* (2011) LRRK2 Parkinson’s disease: from animal models to cellular mechanism. Rev. Neurosci., 22
  8. Lin, C.-H., Tsai, P.-I, Wu, R.-M., Chien, C.-T.* (2010) LRRK2 G2019S Mutation Induces Dendrite Degeneration through Mislocalization and Phosphorylation of Tau by Recruiting Autoactivated GSK3b., J Neurosci.,30(39):13138-13149
  9. Lin, H.-C., Wu, J.-T., Tan, B.-C., Chien, C.-T.* (2009) Cul4 and DDB1 regulate Orc2 localization, BrdU incorporation and Dup stability during gene amplification in Drosophila follicle cells. J Cell Sci., 122:2393-2401.
  10. Ho, M. S., Chen, H., Chen, M., Jacques, C., Giangrande, A.*, Chien, C.-T.* (2009) Gcm protein degradation suppresses proliferation of glial progenitors. Proc Natl Acad Sci USA., 106:6778-83.
  11. Peng, Y.-H., Yang, W.-K., Lin, W.-H., Lai, T.-T., Chien, C.-T.* (2009) Nak regulates Dlg basal localization in Drosophila salivary gland cells. Biochem Biophys Res Commun., 382:108-13.
  12. Knowles, A., Koh, K., Wu, J.-T., Chien, C.-T., Chamovitz, D.-A., Blau, J. (2009) The COP9 signalosome is required for light-dependent timeless degradation and Drosophila clock resetting. J Neurosci., 29, 1152-1162.
  13. Tsai, P.-I., Kao, H.-H., Grabbe, C., Lee, Y.-T., Ghose, A., Lai, T.-T., Peng, K.-P., Van Vactor, D, Palmer R. H., Chen, R.-H., Yeh, S.-R., Chien, C.-T.* (2008) Fak56 functions downstream of integrin alphaPS3betanu and suppresses MAPK activation in neuromuscular junction growth. Neural Dev., 3:26.
  14. Chan, Y., Yoon, J., Wu, J.-T., Kim, H.-J., Pan, K.-T., Yim, J., Chien, C.-T.* (2008) DEN1 deneddylates non-cullin proteins in vivo. J Cell Sci., 121:3218-23. (The first two contribute equally).
  15. Rencus-Lazar, S., Amir, Y., Wu, J., Chien, C.-T., Chamovitz, D.-A., Segal, D. (2008) The proto-oncogene Int6 is essential for neddylation of Cul1 and Cul3 in Drosophila. PLoS One, 3, e2239.
  16. Ho, M. S., Ou, C., Chan, Y., Chien, C. T.* and Pi, H.*. (2008) The utility F-box for protein destruction. Cellular and Molecular Life Sciences, 65: 1977-2000 (invited review).
  17. Ou CY, Wang CH, Jiang J, Chien CT*. (2007) Suppression of Hedgehog signaling by Cul3 ligases in proliferation control of retinal precursors. Dev Biol. 308(1):106-19.
  18. Pi, H.-W., Chien, C.-T.* (2007) Getting the edge: neural precursor selection. J. Biomedical Sci. 14(4):467-73.
  19. Wu, J.-T., Chan Y.-R. and Chien, C.-T.* (2006) Protection of cullin-RING E3 ligases by CSN-UBP12. Trends Cell Biol. 16(7):362-9.
  20. Ho, M. S., Tsai P.-I., and Chien, C.-T.* (2006) F-box proteins: the key to protein degradation. J. Biomedical Sci., 13: 181–191.
  21. Wu, J.-T., Lin S.-C., Hu, Y.-C. and Chien, C.-T., (2005) Neddylation and deneddylation regulate Cul1 and Cul3 protein accumulation. Nat. Cell Biol. 7, 1014-1020.
  22. Pi, H., Huang, S.-K., Tang, C.-Y., Sun, Y.-H. and Chien, C.-T., (2004) phyllopod is a target gene of proneural proteins in Drosophila external sensory organ development. Proc. Natl. Acad. Sci. USA 101, 8378-8383
  23. Ou, C.-Y., Pi, H. and Chien, C.-T., (2003) Control of protein degradation by E3 ubiquitin ligases in Drosophila eye development. Trends Genetics 19, 382-389.
  24. Chou, Y.-H. and Chien, C.-T., (2002) Scabrous controls ommatidial rotation in the Drosophila compound eye. Develop. Cell 3, 839-850.
  25. Ou, C.-Y., Lin, Y.-F., Chen, Y.-J. and Chien, C.-T., (2002) Distinct protein degradation mechanisms mediated by Cul1 and Cul3 controlling Ci stability in Drosophila eye development. Genes & Develop. 16, 2403-2414.
  26. Pi, H., Wu, H.-R., and Chien, C.-T., (2001) A dual function of phyllopod in Drosophila external sensory organ development: cell fate specification of sensory organ precursor and its progeny. Development 128, 2699-2710.
  27. Huang, M.-L., Hsu, C.-H., and Chien, C.-T., (2000) The proneural gene amos promotes multiple dendritic neuron formation in the Drosophila peripheral nervous system. Neuron 25, 57-67.
  28. Chen, C.-K. and Chien, C.-T., (1999) Negative regulation of atonal in proneural cluster formation of Drosophila R8 photoreceptors. Proc. Natl. Acad. Sci. USA 96, 5055-5060.
  29. Tien, A.-C., Hsei, H.-Y., and Chien, C.-T., (1999) Dynamic expression and cellular localization of the Drosophila 14-3-3ε during embryonic development. Mech. Dev. 81, 209-212.