A complete publication list by Yi-Ping Hsueh is available in Google Scholar and Publons
Representative publications since 1995
Hsueh, Y.-P. and Lai, M.-Z. (1995). JNK but not MAP kinase is sensitive to cAMP inhibition in T Lymphocytes. Journal of Biological Chemistry 270: 18094-18098.
Hsueh, Y.-P., Kim, E., and Sheng, M. (1997). Disulfide-linked head-to-head multimerization in the mechanism of ion channel clustering by PSD-95. Neuron 18: 803-814.
Hsueh, Y.-P., Yang, F.-C., Kharazia, V., Naisbitt, S., Cohen, J. M., Weinberg, R. J., and Sheng, M. (1998). Direct interaction of CASK/LIN-2 and syndecan heparan sulfate proteoglycan and their overlapping distribution in neuronal synapses. Journal of Cell Biology 142:139-151.
Hsueh, Y.-P., Wang, T.-F., Yang, F.-C., Sheng M. (2000) Nuclear translocation and transcription regulation by the membrane-associated guanylate kinase CASK/LIN-2. Nature 404:298-302.
Wang, G.-S., Hong, C.-J., Yen, T.-Y., Huang, H.-Y., Ou, Y., Huang, T.-N., Jung, W.-G., Kuo, T.-Y., Sheng, M., Wang, T.-F., and Hsueh, Y.-P. (2004) Transcriptional Modification by a CASK interacting nucleosome assembly protein. Neuron 42:113-128.
Lin, Y.-L., Lei, Y.-T., Hong, C.-J., and Hsueh, Y.-P. (2007) Syndecan-2 induces filopodia and dendritic spine formation via the neurofibromin-PKA-Ena/VASP pathway. Journal of Cell Biology 177:829-841.
Chao, H.-W., Hong, C.-J., Huang, T.-N., Lin, Y.-L., and Hsueh, Y.-P. (2008) SUMOylation of the MAGUK protein CASK regulates dendritic spinogenesis. Journal of Cell Biology 182:141-155. # Selected for early release # Highlighted by Faculty of 1000 Biology
Hsueh, Y.-P.* (2009) Calcium/Calmodulin-Dependent Serine Protein Kinase and Mental Retardation. Annals of Neurology 66:438-443.
Chen, C.-Y., Lin, C.-W., Chang, C.-Y., Jiang, S.-T., and Hsueh, Y.-P. (2011) Sarm1, a negative regulator of innate immunity, interacts with syndecan-2 and regulates neuronal morphology. Journal of Cell Biology 193:769-784.
Wang, H.-F., Shih, Y.-T., Chen, C.-Y., Chao, H.-W., Lee, M.-J., and Hsueh, Y.-P. (2011) Valosin-containing protein and neurofibromin interact to regulate dendritic spine density. Journal of Clinical Investigation 121:4820-4837. Highlighted by a commentary in the same issue of JCI
Huang, T.-N., Chuang, H.-C., Chou, W.-H., Chen, C.-Y., Wang, H.-F., Chou, S.-J., and Hsueh, Y.-P. (2014) Tbr1 haploinsufficiency impairs amygdalar axonal projections and results in cognitive abnormality. Nature Neuroscience 17:240-247. Highlighted by SFARI
Lee, E.-J., Lee, H., Huang, T.-N., Chung, C., Shin, W., Kim, K., Koh, J.-Y., Hsueh, Y.-P. and Kim, E. (2015) Trans-synaptic Zinc mobilization improves social interaction in two mouse models of autism through NMDAR activation. Nature Communications 6:7168.
Shih, Y.-T. and Hsueh, Y.-P. (2016) VCP and ATL1 regulate endoplasmic reticulum and control protein synthesis for dendritic spine formation. Nature Communications 7:11020.
Chen, C.-Y., Liu, H.-Y., and Hsueh, Y.-P. (2017) TLR3 downregulates expression of schizophrenia gene Disc1 via MYD88 to control neuronal morphology. EMBO Reports 18:169-183.
Hung, Y.-F., Chen, C.-Y., Shih, Y.-C., Liu, H.-Y., Huang, C.-M., and Hsueh, Y.-P. (2018) Endosomal TLR3, TLR7, and TLR8 control neuronal morphology through different transcriptional programs. Journal of Cell Biology 217:2727-2742.
Huang, T.-N., Hsu, T.-T., Hu, H.-T., Chuang, H.-C., Sun, T.-F., Tao, M.-H., Lin, J.Y., and Hsueh, Y.-P. (2019) Interhemispheric connectivity potentiates the basolateral amygdalae and regulates social interaction and memory. Cell Reports 29:34-48.
Shih, P.-Y., Hsieh, B.-Y., Lin, M.-H., Huang, T.-N., Tsai, C.-Y., Pong, W.-L., Lee, S.-P., and Hsueh., Y.-P. (2020) CTTNBP2 controls synaptic expression of zinc-related autism-associated proteins and regulates synapse formation and autism-like behaviors. Cell Reports 31: 107700.
Shih, Y.-T., Huang, T.-N., Hu, H.-T., Yen, T.-L., and Hsueh, Y.-P. (2020) Vcp overexpression and leucine supplementation increase protein synthesis and improve fear memory and social interaction of Nf1 mutant mice. Cell Reports 31:107835.
Recent publications (2018~present)
Chen, C.-Y. and Hsueh, Y.-P. (2018) SARM1, sterile alpha and TIR motif containing protein 1. Encyclopedia in Signaling Molecules 4841-4846. ISBN 978-3-319-67198-7, ISBN 978-3-319-67199-4, ISBN 978-3-319-67200-7
Hung, Y.-F., Chen, C.-Y., Shih, Y.-C., Liu, H.-Y., Huang, C.-M., and Hsueh, Y.-P. (Aug, 2018) Endosomal TLR3, TLR7, and TLR8 control neuronal morphology through different transcriptional programs. Journal of Cell Biology 217:2727-2742.
Hung, Y.-F., Chen, C.-Y., Li, W.-C., Wang, T.-F. and Hsueh, Y.-P. (Aug, 2018)Tlr7 deletion alters expression profiles of genes related to neural function and regulates mouse behaviors and contextual memory. Brain, Behavior and Immunity 72:101-113.
Ko, Y.-A., Chan, Y.-H., Liu, C.-H., Liang, J.-J., Chuang, T.-H., Hsueh, Y.-P., Lin, Y.-L., Lin, K.-I. (2018) BLIMP-1-mediated pathway promotes IFN-I production in plasmacytoid dendritic cells by targeting to IRAK-M. Frontiers in Immunology 9:1828.
Liu, H.-Y.#, Chen, C.-Y.#, Hung, Y.-F., Lin, H.-R., Chao, H.-W., Shih, P.-Y., Chuang, C.-N., Li, W.-P., Huang, T.-N. and Hsueh Y.-P. (2018) RNase A promotes proliferation of neuronal progenitor cells via an ERK-dependent pathway. Frontiers in Molecular Neuroscience 11:428. (# co-first author)
Steer, E., Wang, K. Z. Q., Otero, P.A., Bateman, N. W., Cheng, M. H., Scott A. L., Wu., C., Ivert, B., Shih., Y.-T., Hsueh, Y.-P., Chu, C. T. (2018) PINK1 interacts with VCP/p97 and activates PKA to promote NSFL1C/p47 phosphorylation and dendritic arborization in neurons. eNeuro 5:e0466-18.2018.
Shih, Y.-T. and Hsueh, Y.-P. (Dec 2018) The involvement of endoplasmic reticulum formation and protein synthesis efficiency in VCP- and ATL1-related neurological disorders. Journal of Biomedical Science 25:2. (Invited review)
Hsueh, Y.-P. (2019) Synaptic formation, neural circuits and neurodevelopmental disorders controlled by signaling, translation and epigenetic regulation. Developmental Neurobiology 79 (1): 2-7. (Editorial overview for the special issue on “Diseases of Synapse Development and Function”)
Huang, T.-N., Yen, T.-L., Chuang, H.-C. and Hsueh, Y.-P. (2019) Haploinsufficiency of autism high confidence risk gene Tbr1 impairs olfactory discrimination and neuronal activation of the olfactory system in mice. Molecular Autism 10:5. (IF=5.712, 2018)
Chen, C.-Y., Shih, Y.-C., Hung, Y.-F. and Hsueh, Y.-P. (2019) Beyond defense: regulation of neuronal morphology and brain functions via Toll-like receptors. Journal of Biomedical Science 26:90. (PMID: 31684953)(IF=5.203, 2018)
Huang, T.-N., Hsu, T.-T., Hu, H.-T., Chuang, H.-C., Sun, T.-F., Tao, M.-H., Lin, J.Y., and Hsueh, Y.-P. (2019) Interhemispheric connectivity potentiates the basolateral amygdalae and regulates social interaction and memory. Cell Reports 29:34-48. (PMID: 31910261)
Lee, M., Liu, Y.-C., Chen, C., Lu, C.-H., Lu, S.-T., Huang T.-N., Hsu, M.-T., Hsueh, Y.-P., Cheng, P.-L. (2020) Ecm29-mediated proteasomal distribution modulates excitatory GABA responses in the developing brain. Journal of Cell Biology 219:e201903033. (PMID: 31910261)
Hsu, T.-T., Huang, T.-N. and Hsueh, Y.-P. (2020) Anterior commissure regulates neuronal activity of amygdalae and influences locomotor activity, social interaction and fear memory in mice. Frontiers in Molecular Neuroscience 13:47. (PMID: 32296306)
Hsueh, Y.-P.*, Hsu, T.-T. and Huang, T.-N. (2020) The evolutionarily conserved function of TBR1 in controlling the size of anterior commissure in human and mouse brains. European Journal of Human Genetics 28:997-998. (PMID: 32273580)
Shih, P.-Y., Hsieh, B.-Y., Lin, M.-H., Huang, T.-N., Tsai, C.-Y., Pong, W.-L., Lee, S.-P., and Hsueh., Y.-P. (2020) CTTNBP2 controls synaptic expression of zinc-related autism-associated proteins and regulates synapse formation and autism-like behaviors. Cell Reports 31: 107700. (PMID: 32492416)
Shih, Y.-T.#, Huang, T.-N.#, Hu, H.-T.#, Yen, T.-L., and Hsueh, Y.-P.* (2020) Vcp overexpression and leucine supplementation increase protein synthesis and improve fear memory and social interaction of Nf1 mutant mice. Cell Reports 31:107835. (PMID: 32610136)
Shih, P.-Y., Hsieh, B.-Y., Tsai, C.-Y., Lo, C.-A., Chen, B. E. and Hsueh Y.-P.* (2020) Autism-linked mutations of CTTNBP2 reduce social interaction and impair dendritic spine formation via diverse mechanisms. Acta Neuropathologica Communications 8:185. (PMID: 33168105) (IF=6.270, 2019)
Hu, H.-T. and Hsueh, Y.-P. (2020) KLHL17/Actinfilin, a brain-specific gene associated with infantile spasms, regulates dendritic spine enlargement. Journal of Biomedical Science 27:103. (PMID: 33256713) (IF=5.762, 2019)
Huang, T.-N., Shih, Y.-T., Lin, S-C., and Hsueh, Y.-P. (2021) Social behaviors and contextual memory of Vcp mutant mice are sensitive to nutrition and can be ameliorated by amino acid supplementation. iScience 24:101949. (PMID: 3343793)(IF=4.447, 2019)
Li, W.-C., Lee, C.-Y., Lan, W.-H., Woo, T.T., Chen, C.-Y., Yeh, H.-Y., Chang, H.-Y., Liu, H.-C., Chen, C.-L., Chuang, C.-N., Hsueh, Y.-P., Li, H.-W., Chi, P., Wang, T.-F. (2021) Trichoderma reesei Rad51 tolerates mismatches in hybrid meiosis with diverse genome sequences. Proceedings of the National Academy of Sciences 118:e2007192118.
Lin, Y.-L., Lu, M.-Y., Chuang, C.-F., Kup, Y., Lin, H.-E., Lee., F.-A., Wang, J.-R., Hsueh, Y.-P. and Liao F. (2021) TLR7 is critical for antiviral humoral immunity to EV71 infection in the spinal cord. Frontiers in Immunology 11:614743.
Cui, Y., Ma, L., Schacke, S., Yin, J.C., Hsueh, Y.-P., Jin, H. and Morrison, H. (2021) Merlin cooperates with neurofibromin and Spred1 to suppress the Ras–Erk pathway. Human Molecular Genetics 29:3793 (PMID: 33331896)
Lu, M.-H. and Hsueh, Y.-P. (2021) Protein synthesis as a modifiable target for autism-related dendritic spine pathophysiologies. FEBS Journal doi:10.1111/FEBS.15733 (invited “State-of-the-Art” review)(PMID: 3351176)
Hung, Y.-F. and Hsueh, Y.-P. (2021) TLR7 and IL-6 differentially regulate the effects of rotarod exercise on the transcriptomic profile and neurogenesis to influence anxiety and memory. iScience 24:102384.
Chen, C.-Y., Hung, Y.-F., Shih,, Y.-C., Tsai, C.-Y., Chou, T.-F., Lai., M.-Z., Wang, T.-F., and Hsueh, Y.-P. (2021) Transcriptomic analysis and C-terminal epitope tagging reveal differential processing and signaling of endogenous TLR3 and TLR7. Frontiers in Immunology 12:686060.
Chen, C.-Y., Chou, Y.-C. and Hsueh, Y.-P. (2020) SARS-CoV-2 spike D614 and G614 variants impair neuronal synapses and exhibit differential fusion ability. bioRxiv 10.1101/2020.12.03.409763 (https://doi.org/10.1101/2020.12.03.409763)
Chuang, C.N., Woo, T.-T., Tsai, S.-Y., Li, W.-C., Chen, C.-L., Liu, H.-C., Chen, C.-Y., Hsueh, Y.-P., Wang, T.-F. (2020) Intrinsic disorder codes for leaps of protein expression. bioRxiv 10.1101/2020.12.08.407247 (https://doi.org/10.1101/2020.12.08.407247)
Tsai, C.-Y., Chen, C.-Y., Jan, J.-T., Chou, Y.-C., Chang, M.-L., Lu, L.-A., Huang, P.-Y., Chu, M. F.-C., Hsu, T.-T., Hsueh, Y.-P. (2021) Sex-biased response to and brain cell infection by SARS-CoV-2 in a highly susceptible human ACE2 transgenic model. bioRxiv 10.1101/2021.05.04.441029 (https://doi.org/10.1101/2021.05.04.441029)
Shih, P.-Y.#, Fang, Y.-L.#,Shankar, S., Lee, S.-P., Chen, H., Wang, T.-F., Hsia, K.-C.*, Hsueh, Y.-P.* (2022) Phase separation and zinc-induced transition modulate synaptic distribution and association of autism-linked CTTNBP2 and SHANK3. Nature Communications 13:2664 Featured by Nature Communications’ Editor and invited to contribute a blog in “Behind the paper”.