Dr. Hsin-Fang Yang-Yen 楊性芳博士

研究著作

1. Wang, J.-M., Lai, M.-Z., and Yang-Yen, H.-F. 2003. Interleukin-3 stimulation of mcl-1 gene transcription involves activation of the PU.1 transcription factor through a p38 Mitogen-Activated Protein Kinase-dependent Pathway. Mol. Cell. Biol. 23:1896-909.
2. Liu, H., Peng, H.-W., Cheng, Y.-S.,Yuan, H. S., and Yang-Yen, H.-F. 2005. Stabilization and Enhancement of the anti-apoptotic activity of Mcl-1 by TCTP. Mol. Cell. Biol. 25:3117-3126 (cover figure article).
3. Yang-Yen, H.-F. 2006. Mcl-1: a highly regulated cell death and survival controller. J. Biomed. Sci. 13:201-204. (invited review).
4. Chou, C.-H., Lee, R.-S., and Yang-Yen, H.-F. 2006. An internal EELD domain facilitates mitochondrial targeting of Mcl-1 via a Tom70-dependent pathway. Mol. Biol. Cell. 17(9):3952-3963. Epub 2006 Jul 5.
5. Chen, S.-H+., Wu,, P.-S+., Chou, C.-H., Yan, Y.-T., Liu, H., Weng,, S.-Y., and Yang-Yen, H.-F. 2007. A knockout mouse approach reveals that TCTP functions as an essential factor for cell proliferation and survival in a tissue- or cell type- specific manner. Mol. Biol. Cell. 18: 2525-2532. (May 2, 2007,Epub ahead of print)
6. Yang, C.-Y., Lin, N.-H., Lee, J.-M., Huang, C.-Y., Min, H.-J., Yen, J. J.Y., Liao, N.-S., and Yang-Yen, H.-F. 2009. Promoter knock-in mutations reveal a role of Mcl-1 in thymocyte positive selection and tissue or cell-lineage-specific regulation of Mcl-1 expression. J. Immunol. 182(5):2959-2968.
7. Wu, P.-S., Yang. C.-Y., Yen, J. J.-Y., Chou, C.-H., Chen, SH, Wang, C.-K. Leo, Lai, Y.-G., Liao, N.-S., and Yang-Yen, H.-F. 2009. Critical roles of TCTP in the homeostasis and T cell receptor-mediated proliferation of peripheral T cells. J Immunol. 183, 2373-2381.
8. Huang, C.-R., and Yang-Yen, H.-F. 2010. The fast-mobility isoform of mouse Mcl-1 is a mitochondrial matrix-localized protein with attenuated anti-apoptotic activity. FEBS Lett. 584(15), 3323-3330.
9. Weng, S.-Y., Yang, C.-Y., Li, C.-C., Sun, T.-P., Tung, S.-Y., Yen, J. J.-Y., Tsai, T.-F., Chen, C.-M., Chen, S.-H., Hsiao, M., Huang, P.-H., and Yang-Yen, H.-F*. 2011. Synergism between p53 and Mcl-1 in protecting from hepatic injury, fibrosis and cancer. Journal of Hepatology . Journal of Hepatology. 54(4), 685-694.