Chou, J.-Y.*, Hsu, P.-C. and Leu, J.-Y.* “Enforcement of postzygotic species boundaries in the fungal kingdom.” Microbiol. Mol. Biol. Rev. 86(4): e0009822 (2022)
Swamy, K.B.S., Lee, H.-Y., Ladra, C., Liu, C.-F.J., Chao, J.-C., Chen, Y.-Y. and Leu, J.-Y.* “Proteotoxicity caused by perturbed protein complexes underlies hybrid incompatibility in yeast.” Nature Commun. 13: 4394 (2022).
Huang, J.-H., Liao, Y.-R., Lin, T.-C., Tsai, C.-H., Lai, W.-Y., Chou, Y.-K., Leu, J.-Y., Tsai, H.-K.* and Kao, C.-F.*, “iTARGEX analysis of yeast deletome reveals novel regulators of transcriptional buffering in S phase and protein turnover.” Nucleic Acids Res. 49(13): 7318-7329 (2021).
Hsu, P.-C.*, Lu, T.-C., Hung, P.-H., Jhou, Y.-T., Amine, A.A.A., Liao, C.-W. and Leu, J.-Y.* “Plastic rewiring of Sef1 transcriptional networks and the potential of nonfunctional transcription factor binding in facilitating adaptive evolution.” Mol. Biol. Evol. 38(11): 4732-4747 (2021).
Amine, A.A.A., Liao, C.-W., Hsu, P.-C., Opoc, F.J.G. and Leu, J.-Y.*, “Experimental evolution improves mitochondrial genome quality control in Saccharomyces cerevisiae and extends its replicative lifespan.” Curr. Biol. 31: doi: 10.1016/j.cub.2021.06.026 (2021).
Swamy, K.B.S.*, Schuyler, S.C., Leu, J.-Y.*, “Protein complexes form a basis for complex hybrid incompatibility.” Front. Genet. 12: 609766 (2021).
Bozdag, G.O., Ono, J.*, Denton, J.A., Karakoc, E., Hunter, N., Leu, J.-Y. and Greig, D. “Breaking a species barrier by enabling hybrid recombination.” Curr. Biol. 31(2): R180-R181 (2021).
Cheng, Y.-H., Liu, C.-F.J., Yu, Y.-H., Jhou, Y.-T., Fujishima, M., Tsai, I.J. and Leu, J.-Y.* “Genome plasticity in Paramecium bursaria revealed by population genomics.” BMC Biol. 18(1): 180 (2020).
You, S.-T.* and Leu, J.-Y.* “Making sense of noise.” Evolutionary Biology – a Transdisciplinary Approach: Chapter 16: 379-391 (2020).
Cheng, C.-Y., Orias, E., Leu, J.-Y. and Turkewitz, A.P., “The evolution of germ-soma nuclear differentiation in eukaryotic unicells.” Curr. Biol. 30(10): R502-R510 (2020).
Leu, J.-Y., Chang, S.-L., Chao, J.-C., Woods, L.C. and McDonald, M.J.* “Sex alters molecular evolution in diploid experimental populations of S. cerevisiae.” Nature Ecol. Evol. 4(3): 453-460 (2020).
You, S.-T., Jhou, Y.-T., Kao, C.-F. and Leu, J.-Y.* “Experimental evolution reveals a general role for the methyltransferase Hmt1 in noise buffering.” PLoS Biol. 17(10): e3000433 (2019).
Koubkova-Yu, T. C.-T., Chao, J.-C. and Leu, J.-Y.* “Heterologous Hsp90 promotes phenotypic diversity through network evolution.” PLoS Biol. 16(11): e2006450 (2018).
Lee, H.-Y., Chao, J.-C., Cheng, K.-Y. and Leu, J.-Y.* “Misfolding-prone proteins are reversibly sequestered to an Hsp42-associated granule upon chronological aging.” J. Cell Sci. 131(16): jcs220202 (2018).
Lu, T.-C., Leu, J.-Y.* and Lin, W.-C.* “A comprehensive analysis of transcript-supported de novo genes in Saccharomyces sensu stricto yeasts.” Mol. Biol. Evol. 34: 2823-2838 (2017).
Zhou, N., Swamy, K.B.S., Leu, J.-Y., McDonald, M.J., Galafassi, S., Compagno, C. and Piskur, J. “Coevolution with bacteria drives the evolution of aerobic fermentation in Lachancea kluyveri.” PLoS One 12(3): e0173318 (2017).
Gopinath, R.K. and Leu, J.-Y.* “Hsp90 mediates the crosstalk between galactose metabolism and cell morphology pathways in yeast.” Curr. Genet. 63: 23-27 (2017).
Jhuang, H.-Y., Lee, H.-Y. and Leu, J.-Y.* "Mitochondrial-nuclear co-evolution leads to hybrid incompatibility through pentatricopeptide repeat proteins." EMBO Rep. 18: 87-101 (2017).
Lu, Y.-J., Swamy, K.B.S. and Leu, J.-Y.* "Experimental evolution reveals interplay between Sch9 and polyploid stability in yeast." PLoS Genet. 12(11): e1006409 (2016).
McDonald, M.J.*, Yu, Y.-H., Guo, J.-F., Chong, S.-Y., Kao, C.-F. and Leu, J.-Y.* “Mutation at a distance caused by homopolymeric guanine repeats in Saccharomyces cerevisiae.” Sci. Adv. 2: e1501033 (2016).
Gopinath, R.K. and Leu, J.-Y.* Hsp90 maintains proteostasis of the galactose utilization pathway to prevent cell lethality. Mol. Cell. Biol. 36: 1412-1424 (2016).
Lee, H.-Y., Cheng, K.-Y., Chao, J.-C. and Leu, J.-Y.* Differentiated cytoplasmic granule formation in quiescent and non-quiescent cells upon chronological aging. Microbial Cell 3(3): 109-119 (2016).
McDonald, M.J., Chou, C.-H., Swamy, K.B.S., Huang, H.-D. and Leu, J.-Y.* “The evolutionary dynamics of tRNA-gene copy number and codon-use in E. coli.” BMC Evol. Biol. 15: 163 (2015).
Chang, S.-L., Leu, J.-Y.* and Chang, T.-H.* “A population study of killer viruses reveals different evolutionary histories of two closely related Saccharomyces sensu stricto yeasts.” Mol. Ecol. 24: 4312-4322 (2015).
Chou, J.-Y.* and Leu, J.-Y.* “The Red Queen in mitochondria: cyto-nuclear co-evolution, hybrid breakdown and human disease.” Front. Genet. 6: 187 (2015).
Siegal, M.L. and Leu, J.-Y. “On the nature and evolutionary impact of phenotypic robustness mechanisms.” Annu. Rev. Ecol. Evol. Syst. 45: 495-517 (2014).
Gopinath, R.L., You, S.-T., Chien, K.-Y., Swamy, K.B., Yu, J.-S., Schuyler, S.C.* and Leu, J.-Y.* “The Hsp90-dependent proteome is conserved and enriched for hub proteins with high levels of protein-protein connectivity.” Genome Biol. Evol. 6: 2851-2865 (2014).
Kumaran, R., Yang, S.-Y. and Leu, J.-Y.* “Characterization of chromosome stability in diploid, polyploid and hybrid yeast cells.” PLoS One 8(7): e68094 (2013).
Hsieh, Y.-Y., Hung, P.-H., Leu, J.-Y.* “Hsp90 regulates non-genetic variation in response to environmental stress.” Molecular Cell 50: 82-92 (2013).
McDonald, M.J., Hsieh, Y.-Y., Yu, Y.-H., Chang, S.-L. and Leu, J.-Y. “The evolution of low mutation rates in experimental mutator populations of Saccharomyces cerevisiae.” Curr. Biol. 22: 1235-1240 (2012).
Liu, I.-C., Chiu, S.-W., Lee, H.-Y. and Leu, J.-Y.* “The histone deacetylase Hos2 forms an Hsp42-dependent cytoplasmic granule in quiescent yeast cells.” Mol. Biol. Cell 23(7): 1231-1242 (2012).
McDonald, M.J., Wang, W.C., Huang, H.-D.* and Leu, J.-Y.* “Clusters of nucleotide substitutions and insertion/deletion mutations are associated with repeat sequences.” PLoS Biol. 9(6): e1000622 (2011).
Chang, S.-L. and Leu, J.-Y.* “A tradeoff drives the evolution of reduced metal resistance in natural populations of yeast.” PLoS Genet. 7(3): e1002034 (2011).
Chou, J.-Y., Hung Y.-S., Lin, K.-H., Lee, H.-Y. and Leu, J.-Y.* “Multiple molecular mechanisms cause reproductive isolation between three yeast species.” PLoS Biol. 8(7): e1000432 (2010).
Chou, J.-Y. and Leu, J.-Y.* “Speciation through cytonuclear incompatibility: insights from yeast, and implications for higher eukaryotes” BioEssays 32: 401-411 (2010).
Ezov, T.K., Chang, S.-L., Frenkel, Z., Segre, A.V., Bahalul, M., Murray, A.W., Leu, J.-Y., Korol, A. and Kashi, Y. “Heterothallism in S. cerevisiae isolates from nature: effect of HO locus on the mode of reproduction.” Molecular Ecology 19: 121-131 (2010).
Greig, D.* and Leu, J.-Y.* “Natural history of budding yeast.” Curr. Biol. 19: R886-890 (2009).
Lee, H.-Y., Chou, J.-Y., Cheong, L., Chang, N.-H., Yang, S.-Y. andLeu, J.-Y.*"Incompatibility of nuclear and mitochondrial genomes causes hybrid sterility between two yeast species." Cell 135: 1065-1073 (2008)
Segre A. V., A. W. Murray andLeu, J.-Y.* "High-resolution mutation mapping reveals parallel experimental evolution in yeast." PLoS Biol. 4: 1372-1385 (2006).
Leu, J.-Y.* and Murray, A.W. "Experimental
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