Liuh-Yow Chen Lab

Dr. Liuh-Yow Chen 陳律佑 博士
Associate Research Fellow, IMB

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Publications

Selected Recent Publications

  1. Chen CF, Sung TL, Chen LY*, Chen JH. (2018) Telomere maintenance during anterior regeneration and aging in fresh water annelid Aeolosoma viride. Scientific Reports. 8(1):18078
  2. Khoo LT, Chen LY*. (2018) Role of the cGAS-STING pathway in cancer development and potential as a cancer therapeutic target. EMBO Reports. 19(12)
  3. Chen YA, Shen YL, Hsia HY, Tiang YP, Sung TL, Chen LY*. (2017) Extrachromosomal telomere repeat DNA is linked to ALT development via cGAS-STING DNA sensing pathway. Nat. Struct. Mol. Biol. 24(12), 1124-31
  4. Chen RL, Lin HT, Chen LY. (2017) Chemotherapy for extracranial germ cell tumors in paediatric, adolescent, and young adult patients. EMJ Oncology 5[1]:93-102 
  5. Feuerhahn S, Chen LY, Luke B, Porro A. (2015) No DDrama at chromosome ends: TRF2 takes centre stage. Trends Biochem Sci. 40(5), 275-85
  6. Chen LY , Majerská J, Lingner J. (2013) Molecular basis of telomere syndrome caused by CTC1 mutations. Genes Dev. 27, 2099-108.
  7. Chen LY and Lingner J. (2013) CST for the grand finale of telomere replication. Nucleus 4, 277-82.
  8. Zhang Y, Chen LY, Han X, Hie W, Kim H, Yang D, Liu D, Songyang Z. (2013) Phosphorylation of TPP1 regulates cell cycle-dependent telomerase recruitment. Proc Natl Acad Sci U S A.  110, 5457-62.
  9. Chen LY, Zhang Y, Li H, Zhang Q, Fang H, Yotnda P, Kim SH, Qin L, Xu J, Tu B, Bai Y, Sonagyang Z. (2012) Mitochondrial Localization of telomeric protein TIN2 links telomere regulation to metabolic control. Mol. Cell 47, 839-850.
  10. Chen LY, Redon S, and Lingner J. (2012) The human CST complex is a terminator of telomerase activity. Nature 488, 540-544.
  11. Chen LY and Lingner J. (2012) AUF1/hnRNP D RNA binding protein functions in telomere maintenance. Mol Cell 47, 1-2.
  12. Zheng ZY, Cheng CM, Fu XR, Chen LY, Xu L, Terrillon S, Wong ST, Bar-Sagi D, Songyang Z, and Chang EC. (2012) CHMP6 and VPS4A mediate the recycling of Ras to the plasma membrane to promote growth factor signaling. Oncogene10.1038/onc.2011.607.
  13. Lee OH, Kim H, He Q, Baek HJ, Yang D, Chen LY, Liang J, Chae HK, Safari A, Liu D, and Songyang Z. (2011) Genome-wide YFP fluorescence complementation screen identifies new regulators for telomere signaling in human cells. Mol Cell Proteomics 10, M110 001628.
  14. Kim H, Lee OH, Xin H, Chen LY, Qin J, Chae HK, Lin SY, Safari A, Liu D, and Songyang Z. (2009) TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs. Nat Struct Mol Biol 16, 372-379.
  15. Yeung PL, Chen LY, Tsai SC, Zhang A, and Chen JD. (2008) Daxx contains two nuclear localization signals and interacts with importin alpha3. J Cell Biochem 103, 456-470.
  16. Chen LY, Liu D, and Songyang Z. (2007) Telomere maintenance through spatial control of telomeric proteins. Mol Cell Biol 27, 5898-5909.
  17. Johnson DR, Li CW, Chen LY, Ghosh JC, and Chen JD. (2006) Regulation and binding of pregnane X receptor by nuclear receptor corepressor silencing mediator of retinoid and thyroid hormone receptors (SMRT). Mol Pharmacol 69, 99-108.
  18. Chen LY, and Chen JD. (2003) Daxx silencing sensitizes cells to multiple apoptotic pathways. Mol Cell Biol 23, 7108-7121.
  19. Chang WM, Chen KD, Chen LY, Lai MT, and Lai YK. (2003) Mitochondrial calcium-mediated reactive oxygen species are essential for the rapid induction of the grp78 gene in 9L rat brain tumour cells. Cell Signal 15, 57-64.
  20. Liao G, Chen LY, Zhang A, Godavarthy A, Xia F, Ghosh JC, Li H, and Chen JD. (2003) Regulation of androgen receptor activity by the nuclear receptor corepressor SMRT. J Biol Chem 278, 5052-5061.
  21. Chen KD, Lai MT, Cho JH, Chen LY, and Lai YK. (2000) Activation of p38 mitogen-activated protein kinase and mitochondrial Ca(2+)-mediated oxidative stress are essential for the enhanced expression of grp78 induced by the protein phosphatase inhibitors okadaic acid and calyculin A. J Cell Biochem 76, 585-595.
  22. Chen LY, Chiang AS, Hung JJ, Hung HI, and Lai YK. (2000) Thapsigargin-induced grp78 expression is mediated by the increase of cytosolic free calcium in 9L rat brain tumor cells. J Cell Biochem 78, 404-416.
  23. Chen KD, Chen LY, Huang HL, Lieu CH, Chang, YN, Chang MD, and Lai YK. (1998) Involvement of p38 mitogen-activated protein kinase signaling pathway in the rapid induction of the 78-kDa glucose-regulated protein in 9L rat brain tumor cells. J Biol Chem 273, 749-755.