Dr. Chwan-Deng (David) Hsiao ¿½¶Çôñ³Õ¤h

Research Fellow, IMB

Publications

  1. Hsiao, C.-D. , Sun, Y.-J., Rose, J. and Wang, B.-C. (1996). The crystal structure of glutamine-binding protein from Escherichia coli. J. Mol. Biol. 262 , 225-242. [PubMed] [PDB]
  2. Chien, C.-T., Hsiao, C.-D. , Jan, L. Y. and Jan Y. N. (1996) Neuronal type information encoded in the basic-helix-loop-helix domain of proneural genes. Proc. Natl. Acad. Sci. USA 93 , 13239-13244. [PubMed]
  3. Sun, Y.-J., Wu, W.-q., Chiang, C.-M., Hsin, A.-Y. and Hsiao, C.-D. (1997) Crystal structure of cardiotoxin V from Taiwan cobra venom: pH dependent conformational change and a novel membrane binding motif identified in the three-finger loops of P-type cardiotoxin. Biochemistry 36 , 2403-2413. [PubMed] [PDB]
  4. Sun, Y.-J., Rose, J., Wang, B.-C., and Hsiao, C.-D. (1998) The structure of glutamine-binding protein complexed with glutamine at 1.94A resolution: Comparisons with other amino acid binding proteins. J. Mol. Biol. 278 , 219-229. [PubMed] [PDB]
  5. Sun, Y.-J., Kuan, I.-C., Tam, M. F. and Hsiao, C.-D. (1998) The three-dimensional structure of an avian class-mu glutathione S-Transferase, cGSTM1-1 at 1.94A resolution. J. Mol. Biol. 278 , 239-252. [PubMed] [PDB]
  6. Sun, Y.-J., Chou, C.-C., Chen, W.-S., Wu, R.-T., Meng, M. and Hsiao, C.-D. (1999) The crystal structure of a multifunctional protein: phosphoglucoseisomerase/autocrine motility factor/neuroleukin. Proc. Natl. Acad. Sci. USA 96 , 5412-5417. [PubMed] [PDB]
  7. Chou, C.-C., Sun, Y.-J., Meng, M. and Hsiao, C.-D. (2000) The crystal structure of phosphoglucose isomerase/autocrine motility factor/neuroleukin complexed with its carbohydrate phosphate inhibitors suggests its substrate/receptor recognition. J. Biol. Chem . 275 , 23154-23160. [PubMed] [PDB] [PDB]
  8. Sun, Y.-J., Chang, N.-C., Hung, Shuen-Iu, Chang, A. C. Chou, C.-C., and Hsiao, C.-D. (2001). The crystal structure of a novel mammalian lectin, Ym1, suggests a saccharide binding surface. J. Biol. Chem . 276 , 17507-17514. [PubMed] [PDB]
  9. Sun, Y.-J.*, Forouhar, F.*, Li, H.-M., Tu, S.-L., Kao, S., Shr, H.-L., Yeh, Y.-H., and Hsiao, C.-D. (2002). Crystal structure of pea Toc34 - a novel GTPase of the chloroplast protein translocon. Nat. Struct. Biol. 9 , 95-100. (* these authors contributed equally to this work). [PubMed] [PDB]
  10. Forouhar, F., Huang, W.-N., Liu, J.-H., Chien, K.-Y., Wu, W.-g. and Hsiao, C.-D. (2003). Structural basis of the membrane-induced cardiotoxin A3 oligomerization. J. Biol. Chem. 278 , 21980-21988. [PubMed] [PDB]
  11. Chou, C.-C., Forouhar, F., Yeh, Y.-H., Shr, H.-L. Wang, C. and Hsiao, C.-D. (2003). Crystal structure of the C-terminal 10 kDa subdomain of Hsc70. J. Biol. Chem. 278 , 30311-30316. [PubMed] [PDB]
  12. Liu, J.-H., Chang, T.-W., Huang, C.-Y., Chen, S.-U., Wu, H.-N., Chang, M.-C., Hsiao, C.-D. (2004) Crystal structure of PriB, a primosomal DNA replication protein of Escherichia coli . J. Biol. Chem. 279 , 50465-50471. [PubMed] [PDB]
  13. Wang, C.-H., Liu, J.-H., Lee, S.-C., Wu, W.-G., and Hsiao, C.-D.(2006). Glycosphingolipid-facilitated membrane insertion and internalization of cobra cardiotoxin: the sulfatide/cardiotoxin complex structure in a membrane-like environment suggests a lipid-dependent cell-penetrating mechanism for membrane binding polypeptides. J. Biol. Chem. 281, 656-677.[PubMed][PDB]
  14. Tsai, K.-L., Huang, C.-Y., Chang, C.-H., Sun, Y.-J., Chuang, W.-J. and Hsiao, C.-D.(2006). Crystal structure of the human FOXK1a/DNA complex and its implications on the diverse binding specificity of winged helix/forkhead proteins. J. Biol. Chem. 281, 17400-17409.[PubMed][PDB]
  15. Huang, C.-Y., Hsu, C.-H., Sun, Y.-J., Wu, H.-N. and Hsiao, C.-D.(2006) Complexed crystal structure of replication restart primosome protein PriB reveals a novel single-stranded DNA binding mode. Nucleic Acids Res. 34, 3878-3886.[PubMed][PDB]
  16. Yeh, Y.-H., Kesavulu, M.M., Li, H.-m., Wu, S.-Z., Sun, Y.-J., Konozy, E.H.E., and Hsiao, C.-D. (2007) Dimerization is important for the GTPase activity of chloroplast translocon components atToc33 and psToc159. J. Biol. Chem. 282, 13845-13853. [PubMed][PDB]
  17. Tsai, K.-L., Sun, Y.-J., Huang, C.-Y., Yang, J.-Y., Hung, M.-C., and Hsiao, C.-D. (2007) Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification. Nucl. Acids Res. 35, 6984-6994.
  18. Chang, Y.-W., Sun, Y.-J., Wang, C., and Hsiao, C.-D. (2008) Crystal structures of the 70-kDa heat shock proteins in domain disjoining conformation. J. Biol. Chem. (in press)
[ LSL Publication Database ]