Dr. Michael M.C. Lai 賴明詔博士

Distinguished Research Fellow, IMB

Publications

  1. Chen YC, Su WC, Huang JY, Chao TC, Jeng KS, Machida K, Lai MM. (2010) Polo-like kinase 1 is involved in hepatitis C virus replication by hyperphosphorylating NS5A. J Virol. 84(16):7983-93.
  2. Machida K, Tsukamoto H, Liu JC, Han YP, Govindarajan S, Lai MM, Akira S, Ou JH. (2010) c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair. Hepatology. 52(2):480-92.
  3. Machida K, McNamara G, Cheng KT, Huang J, Wang CH, Comai L, Ou JH, Lai MM. (2010) Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes. J Immunol. 185(11):6985-98.
  4. Su CY, Cheng TJ, Lin MI, Wang SY, Huang WI, Lin-Chu SY, Chen YH, Wu CY, Lai MM, Cheng WC, Wu YT, Tsai MD, Cheng YS, Wong CH. (2010) High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity. Proc Natl Acad Sci U S A. 107(45):19151-6.
  5. Lai CK, Jeng KS, Machida K, Lai MM. (2010) Hepatitis C virus egress and release depends on endosomal trafficking of core protein. J Virol. 84:11590-8.
  6. Liao TL, Wu CY, Su WC, Jeng KS and Lai MM. (2010) Ubiquitination and deubiquitination of NP protein regulates influenza A virus RNA replication. The EMBO Journal 29:3879-90.
  7. Wu CY, Jeng KS, Lai MM. (2011) The SUMOylation of Matrix Protein M1 Modulates the Assembly and Morphogenesis of Influenza A Virus. J Virol. 85:6618-28.
  8. Wang L, Jeng KS, Lai MM. (2011) Poly(C)-binding protein 2 Interacts with sequences Required for Viral Replication in HCV 5' UTR and Directs HCV RNA Replication through Circularizing the Viral Genome. J Virol. 85:7954-64.
  9. Su WC, Chao TC, Huang YL, Weng SC, Jeng KS, Lai, MM. (2011) Rab5 and Class III Phosphoinositide 3-Kinase Vps34 Are Involved in Hepatitis C Virus NS4B-Induced Autophagy. J Virol. 2011 85:10561-71.
  10. Chao TC, Su WC, Huang JY, Chen YC, Jeng KS, Wang HD, Lai MM. (2012) PSTPIP2, Proline-Serine-Threonine Phosphatase Interacting Protein 2, a Host Membrane-Deforming Protein, is critical for Membranous Web Formation in Hepatitis C Virus replication. J.Virol. 86(3): 1739-49.
  11. Saxena V, Lai CK, Chao TC, Jeng KS, Lai MM. (2012) Annexin A2 is involved in the formation of hepatitis C virus replication complex on the lipid raft. J Virol. 2012 86(8):4139-50.
  12. Huang JY, Su WC, Jeng KS, Chang TH, Lai MM. Attenuation of 40S Ribosomal Subunit Abundance Differentially Affects Host and HCV Translation and Suppresses HCV Replication. PLoS Pathog. 2012 Jun;8(6):e1002766. Epub 2012 Jun 28.
  13. Su WC, Chen YC, Tseng CH, Hsu PW, Tung KF, Jeng KS, Lai MM. (2013). Pooled RNAi screen identifies ubiquitin ligase Itch as crucial for influenza A virus release from the endosome during virus entry. Proc Natl Acad Sci U S A. 2013 Oct 7. [Epub ahead of print]
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