Dr. Michael M.C. Lai 賴明詔博士
分生所客座講座
研究著作
- Chen YC, Su WC, Huang JY, Chao TC, Jeng KS, Machida K, Lai MM. (2010) Polo-like kinase 1 is involved in hepatitis C virus replication by hyperphosphorylating NS5A. J Virol. 84(16):7983-93.
- Machida K, Tsukamoto H, Liu JC, Han YP, Govindarajan S, Lai MM, Akira S, Ou JH. (2010) c-Jun mediates hepatitis C virus hepatocarcinogenesis through signal transducer and activator of transcription 3 and nitric oxide-dependent impairment of oxidative DNA repair. Hepatology. 52(2):480-92.
- Machida K, McNamara G, Cheng KT, Huang J, Wang CH, Comai L, Ou JH, Lai MM. (2010) Hepatitis C virus inhibits DNA damage repair through reactive oxygen and nitrogen species and by interfering with the ATM-NBS1/Mre11/Rad50 DNA repair pathway in monocytes and hepatocytes. J Immunol. 185(11):6985-98.
- Su CY, Cheng TJ, Lin MI, Wang SY, Huang WI, Lin-Chu SY, Chen YH, Wu CY, Lai MM, Cheng WC, Wu YT, Tsai MD, Cheng YS, Wong CH. (2010) High-throughput identification of compounds targeting influenza RNA-dependent RNA polymerase activity. Proc Natl Acad Sci U S A. 107(45):19151-6.
- Lai CK, Jeng KS, Machida K, Lai MM. (2010) Hepatitis C virus egress and release depends on endosomal trafficking of core protein. J Virol. 84:11590-8.
- Liao TL, Wu CY, Su WC, Jeng KS and Lai MM. (2010) Ubiquitination and deubiquitination of NP protein regulates influenza A virus RNA replication. The EMBO Journal 29:3879-90.
- Wu CY, Jeng KS, Lai MM. (2011) The SUMOylation of Matrix Protein M1 Modulates the Assembly and Morphogenesis of Influenza A Virus. J Virol. 85:6618-28.
- Wang L, Jeng KS, Lai MM. (2011) Poly(C)-binding protein 2 Interacts with sequences Required for Viral Replication in HCV 5' UTR and Directs HCV RNA Replication through Circularizing the Viral Genome. J Virol. 85:7954-64.
- Su WC, Chao TC, Huang YL, Weng SC, Jeng KS, Lai, MM. (2011) Rab5 and Class III Phosphoinositide 3-Kinase Vps34 Are Involved in Hepatitis C Virus NS4B-Induced Autophagy. J Virol. 2011 85:10561-71.
- Chao TC, Su WC, Huang JY, Chen YC, Jeng KS, Wang HD, Lai MM. (2012) PSTPIP2, Proline-Serine-Threonine Phosphatase Interacting Protein 2, a Host Membrane-Deforming Protein, is critical for Membranous Web Formation in Hepatitis C Virus replication. J.Virol. 86(3): 1739-49.
- Saxena V, Lai CK, Chao TC, Jeng KS, Lai MM. (2012) Annexin A2 is involved in the formation of hepatitis C virus replication complex on the lipid raft. J Virol. 2012 86(8):4139-50.
- Huang JY, Su WC, Jeng KS, Chang TH, Lai MM. Attenuation of 40S Ribosomal Subunit Abundance Differentially Affects Host and HCV Translation and Suppresses HCV Replication. PLoS Pathog. 2012 Jun;8(6):e1002766. Epub 2012 Jun 28.
- Su WC, Chen YC, Tseng CH, Hsu PW, Tung KF, Jeng KS, Lai MM. (2013). Pooled RNAi screen identifies ubiquitin ligase Itch as crucial for influenza A virus release from the endosome during virus entry. Proc Natl Acad Sci U S A. 2013 Oct 7. [Epub ahead of print]