真菌與線蟲的分子交互作用及共同演化
線蟲是地球上數量最多的動物。據估計，地球表層土壤中存在約有 4 x 1020 的線蟲，而許多線蟲是寄生性線蟲，造成人類，動物，及植 物的各種疾病。全球估計有超過十億人口受到寄生蟲的感染，而在 農業上，每年因寄生性線蟲在各種作物造成的經濟損失則高達800 億美金。目前人類可以使用的抗寄生蟲藥物種類並不多，以伊維菌 素（Ivermectin）最為普遍。近年來伊維菌素抗藥性問題日趨嚴重， 因此我們急需發展新型抗寄生蟲藥物或是新的方法，來防治寄生性線 蟲。在自然界中，線蟲存在於復雜的群落中，依靠著精細的化學信號 網絡與其他物種產生交互作用，其中亦包括了線蟲的天敵，食線蟲真 菌。許多不同的真菌例如線蟲捕捉菌及杏鮑菇，秀珍菇，蠔菇等側耳 屬菇類在演化的過程中，獨立演化出捕食線蟲的能力，從線蟲獲取養 分。食蟲真菌和線蟲之間的天敵關係使它們成為研究種間交互作用和 掠食者/ 獵物之間共同演化的理想系統。本實驗室建立了線蟲捕捉菌及蠔菇兩種非模式生物的分子遺傳系統，並利用秀 麗隱桿線蟲來系統性的研究肉食性真菌獵食，毒殺線蟲的分子機制及掠食者/ 獵物之間共同演化。本實驗室採用的系統 性方法包含遺傳學，基因體學，分子生物學，生物化學，影像分析，細胞生物學，神經科學，及化學分析等，聚焦回 答以下幾個主要問題：
- 線蟲捕捉菌偵測線蟲費洛蒙，發育捕捉構造的分子機制
- 線蟲捕捉菌黏著，侵染線蟲獵物的的分子機制
- 線蟲捕捉菌捕食線蟲能力的演化
- 蠔菇毒殺線蟲成分的分析
- 蠔菇發育特殊毒殺線蟲構造的分子機制
- 秀麗隱桿線蟲偵測掠食者的神經分子機制
- 秀麗隱桿線蟲對掠食者的行為演化
- PDF, 2010-2015, Division of Biology and Biological Engineering, California Institute of Technology
- Ph.D., 2008-2010, Department of Molecular Genetics and Microbiology, Duke University
- MS, 2003, Department of Plant Pathology and Microbiology, National Taiwan University
- BS, 2001, Department of Plant Pathology and Microbiology, National Taiwan University
- 2022, 中央研究院年輕學者研究成果獎
- 2022, 台灣傑出女科學家新秀獎
- 2021, 李天德青年醫藥科技獎
- 2020, 歐洲分子生物學組織年輕學者
- 2019, 歐洲分子生物學組織全球學者
- 2018, 傑出人才基金會年輕學者創新獎
- 2014, NIH/NIGMS Pathway to Independence (PI) K99 Award
- 2008, Genetics Society of America, DeLill Nasser Award
- Ching-Han Lee, Yi-Yun Lee, Yu-Chu Chang, Wen-Li Pon, Sue-Ping Lee, Niaz Wali, Takehito Nakazawa, Yoichi Honda, Jiun-Jie Shie, Yen-Ping Hsueh (2023) A carnivorous mushroom paralyzes and kills nematodes via a volatile ketone. SCIENCE ADVANCES 18 Jan 2023 Vol 9, Issue 3.
- Sheng-An Chen, Hung-Che Lin, Yen-Ping Hsueh (2022) The cAMP-PKA pathway regulates prey sensing and trap morphogenesis in the nematode-trapping fungus Arthrobotrys oligospora. G3 Genes|Genomes|Genetics 12, jkac217 (Cover)
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- Tsung-Yu Huang, Yi-Yun Lee, Guillermo Vidal-Diez de Ulzurrun, Yen-Ping Hsueh (2021) Forward genetic screens identified mutants with defects in trap morphogenesis in the nematode-trapping fungus Arthrobotrys oligospora. G3 11: jkaa022.
- Yi-Yun Lee, Guillermo Vidal-Diez de Ulzurrun, Erich M Schwarz, Jason E Stajich, Yen-Ping Hsueh (2021) Genome sequence of the oyster mushroom Pleurotus ostreatus strain PC9. G3 11: jkaa008.
- Ching-Ting Yang, Guillermo Vidal-Diez de Ulzurrun, A Pedro Gonçalves, Hung-Che Lin, Ching-Wen Chang, Tsung-Yu Huang, Sheng-An Chen, Cheng-Kuo Lai, Isheng J Tsai, Frank C Schroeder, Jason E Stajich, Yen-Ping Hsueh (2020) Natural diversity in the predatory behavior facilitates the establishment of a robust model strain for nematode- trapping fungi. PNAS 117: 6762-6770.
- Ching-Han Lee, Han-Wen Chang, Ching-Ting Yang, Niaz Wali, Jiun-Jie Shie, Yen-Ping Hsueh (2020) Sensory cilia as the Achilles heel of nematodes when attacked by carnivorous mushrooms. PNAS 117: 6014-6022.
- Guillermo Vidal-Diez de Ulzurrun, Tsung-Yu Huang, Ching-Wen Chang, Hung-Che Lin, Yen-Ping Hsueh (2019) Fungal feature tracker (FFT): A tool for quantitatively characterizing the morphology and growth of filamentous fungi. PLoS Comput Biol. 15: e1007428.
- Yen-Ping Hsueh, Matthew R Gronquist, Erich M Schwarz, Ravi David Nath, Ching-Han Lee, Shalha Gharib, Frank C Schroeder, Paul W Sternberg (2017) Nematophagous fungus Arthrobotrys oligospora mimics olfactory cues of sex and food to lure its nematode prey. eLife 6: e20023.
