The vaccinia virus WR53.5L/F14.5L gene encodes a small conserved protein that was not detected previously. However, additional proteomic analyses of different vaccinia virus isolates and strains revealed that the WR53.5 protein was incorporated into intracellular mature virus (IMV). The WR53.5 protein contains a putative N-terminal transmembrane region and a short C-terminal region... J. Virol. doi:10.1128/JVI.00816-08 Read more...

The Pax gene eyg is important for Drosophila eye development. eyg expression in the visual system changes dynamically during development. In this study, we found that the transcriptional regulation of eyg can be separated into four distinct temporal phases (E, L1, L2, and L3) and each is regulated by distinct cis regulatory elements. Utilizing these enhancers for temporal and spatially specific manipulations, we addressed the regulation and function of eyg at different developmental stages... Dev Biol. 2008 Jul 4. Read more...

Nuclear pre–messenger RNA (pre-mRNA) splicing is an essential processing step for the production of mature mRNAs from most eukaryotic genes. Splicing is catalyzed by a large ribonucleoprotein complex, the spliceosome, which is composed of five small nuclear RNAs and more than 100 protein factors. Despite the complexity of the spliceosome, the chemistry of the splicing reaction is simple, consisting of two consecutive transesterification reactions... Science 320, 1782-1784. Read more...