Research
Receptor and Channel Function
My lab investigates the molecular basis of neuronal electric excitability. We explore the molecular mechanism with which cells detect environmental stress. Our primary research focus is sensory transduction, the process by which primary sensory neurons generate electric signals. We use a variety of methods ranging from molecular biology, physiology, pharmacology to biophysics to dissect the transduction mechanism.
研究神經系統轉譯物理或化學性刺激成為電學訊號的分子機制。原則上，周邊神經末梢表達特殊的信號接受器來偵測各種不同性質的感覺刺激。這些接受器大多是隨著刺激的強度而有不同開啟程度的離子通道。離子的通透量決定電流的大小，以及之後神經細胞的興奮程度。實驗室主要研究細胞如何調控這類離子通道的專一性及敏感度。這些接受器利用什麼特殊的蛋白質結構來分辨不同的物理因子？細胞內的那些生化反應能產生調節性的化學分子來重新設定信號接受器的靈敏度和反應強度？我們的應用目標是希望藉由人為操縱神經系統對感官訊息的轉譯效率，來治療病理性的疼 痛或其他的感覺神經系統障礙。
Experience
| 2012.12 – | Associate Research Fellow, Institute of Molecular Biology, Academia Sinica, Taipei, Taiwan |
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| 2006 –2012 | Assistant Professor of Molecular Physiology, Department of Biomedical Sciences, Cornell University, Ithaca, NY
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| 2003-2005 | Assistant Research Pharmacologist, Department of Molecular Pharmacology University of California, San Francisco | |
| 1999-2002 | Postdoctoral Fellow, Department of Molecular Pharmacology University of California, San Francisco | |
| 1997-1998 | Postgraduate Researcher, Department of Physiology University of California, San Francisco | |
| 1989-1992 | Clinical Residency, Department of Obstetrics and Gynecology National Taiwan University Hospital, Taipei, Taiwan | |
| 1997 | Ph.D. | Biomedical Sciences, University of California, San Francisco |
| 1989 | M.D. | National Taiwan University, Taipei, Taiwan |
老師的話
