蛋白質輸入色質體的機制
植物的色質體(plastid)依所在組織的不同,發育成不同功能的胞器。例如在葉肉細胞中,就發育成執行光合作用的葉綠體,在根細胞中就發育成儲存養份的白色體。
大多數的色質體蛋白是在細胞質中合成,然後送入色質體。這些蛋白能否被正確地送入色質體,乃是決定色質體能否正常運作的最大關鍵。
要進入色質體的蛋白,在細胞質合成時,前端皆多了一段導引訊息(transit peptide)。他們進入色質體的過程需要一組位於色質體膜中的運輸機組(translocon)的幫助。
我們以遺傳及生化學的方法,研究蛋白質輸入色質體的分子機制。我們發現運輸機組乃受植物組織與年紀調控,並找到了導引訊息中讓不同組織色質體辨識的組件。藉由研究各個運輸機組成員之間的組合與交互作用,我們逐步呈現蛋白質進入色質體的分子步驟。
我們並找到了連接色質體內外膜運輸機組的橋樑蛋白,對此蛋白的分析顯示,色質體運輸機組的骨架乃是從細菌的一個分泌系統演化而來。

- PDF, 1992-1995, Plant Biology Lab., Salk Institute, USA
Plant Biology Div., Noble Foundation,
USA
- Ph.D., 1992, Cell & Molec. Biol. Program,
U. Wisconsin-Madison, USA
- BS, 1986, Dept. Botany, Natl. Taiwan Univ.
- 2023 Outstanding in Teaching Award, National Taiwan University 台灣大學 教學傑出獎
- 2022 Outstanding Women in Science 台灣傑出女科學家獎
- 2020 American Society of Plant Biologists Enid MacRobbie corresponding membership award 美國植物學家學會終生會員獎
- 2020, 2021, 2022 Excellence in Teaching Award, College of Life Science, National Taiwan University 台灣大學 教學優良獎
- 2019 Academic Award of Ministry of Education 教育部 學術獎
- 2008, 2019 Shu-Chen Grace Chen Distinguished Lectureship 陳淑真研究員學術講座
- 2018 侯金堆傑出榮譽獎
- 2019-2024, 2014-2019, 2009-2014, 2004-2009, 1998-2003 Frontier Science Grant, Ministry of Science and Technology, Taiwan 國科會尖端科技研究計畫
- 1999-2000, 2001-2002, 2005-2007 Research Excellence Award, National Science Council, Taiwan 國科會傑出獎
- 1999 Youth Medal, Chinese Youth Corp. Taiwan 救國團青年奬章
- 1998 Young Investigator Publication Award, Academia Sinica, Taiwan 中研院年輕人員著作奬
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