Dr. Yu, Su-May - April, 2024
Root architecture and function are critical for plants to secure water and nutrient supply from the soil, but environmental stresses alter root development. The phytohormone jasmonic acid (JA) regulat ...
Dr. Hsueh, Yen-Ping - April, 2024
The capability to sense and respond to the environment is essential for survival and fitness in all organisms. Recent studies hav ...
Dr. Chen, Jun-An - February, 2024
Long noncoding RNAs (lncRNAs) play pivotal roles in modulating gene expression during development and disease. Despite their high expression in the central nervous system (CNS), understanding the prec ...
Dr. Wang, Ting-Fang - February, 2024
Serine(S)/threonine(T)-glutamine(Q) cluster domains (SCDs), polyglutamine (polyQ) tracts and polyglutamine/asparagine (polyQ/N) tracts are Q-rich motifs found in many proteins. SCDs often are intrinsi ...
Dr. Hsueh, Yi-Ping - February, 2024
Many genes with distinct molecular functions have been linked to genetically heterogeneous amyotrophic lateral sclerosis (ALS), including SuperOxide Dismutase 1 (SOD1) and Valosin-Containing Protein ( ...
Dr. Hsueh, Yi-Ping - February, 2024
Efficiently delivering exogenous materials into primary neurons and neural stem cells (NSCs) has long been a challenge in neurobiology. Existing methods have struggled with complex protocols, unreliab ...
Dr. Hsueh, Yen-Ping - November, 2023
Nematodes are ubiquitous in soil and are the most abundant animals on Earth. Some fungi have evolved the ability to prey on nematodes in nutrient-deficient environments. To gain deeper insights into t ...
Dr. Chang, Wen - November, 2023
Virus-mediated membrane fusion involves conformational changes of the viral fusion protein to fuse the opposing viral and host lipid bilayers. Unlike all other known viruses that contain a single fusi ...
Dr. Chang, Wen - November, 2023
Host cell entry of vaccinia virus (a poxvirus) proceeds through multiple steps that involve many viral proteins to mediate cell infection. Upon binding to cells, vaccinia virus membrane fuses with hos ...
Dr. Cheng, Soo-Chen - October, 2023
The DExD/H-box RNA helicase Prp16 plays a pivotal role in the splicing process. Following the branching reaction, it utilizes its ATP-dependent functions to facilitate exon ligation by displacing step ...
Dr. Li, Hsou-min - September, 2023
Protein import into chloroplasts is powered by ATP hydrolysis in the stroma. Establishing the identity and functional mechanism of the stromal ATPase motor that drives import is critical for understan ...
Dr. Hsia, Kuo-Chiang - September, 2023
The transcription factor TATA-box binding protein (TBP) modulates gene expression in nuclei. This process requires the involvement of nuclear transport receptors, collectively termed karyopherin- (Ka ...
Dr. Hsueh, Yi-Ping - September, 2023
Dendritic spines, the tiny and actin-rich protrusions emerging from dendrites, are the subcellular locations of excitatory synapses in the mammalian brain that control synaptic activity and plasticity ...
Dr. Sun, Y. Henry - August, 2023
Phenotypic heterogeneity is very common in genetic systems and in human diseases and has important conse‑quences for disease diagnosis and treatment. In addition to the many genetic and non‑genetic (e ...
Dr. Shen, Che-Kun James - July, 2023
A causal relationship exists among the aging process, organ decay and dis-function, and the occurrence of various diseases including cancer. A genetically engineered mouse model, termed EklfK74R/K74R ...
Dr. Cheng, Pei-Lin - June, 2023
Biomechanical inputs are ubiquitously present in biological systems and are known to regulate various cell functions. In particular, neural cell development is sensitive to mechanical regulation, as t ...
Dr. Leu, Jun-Yi - May, 2023
Enhanced phenotypic diversity increases a population’s likelihood of surviving catastrophic conditions. Hsp90, an essential molecular chaperone and a central network hub in eukaryotes, has been observ ...
Dr. Hsueh, Yi-Ping - May, 2023
Synaptopathy, which encompasses morphological deficits and any abnormal protein distribution of synapses, is a critical feature of many neurological diseases. We here provide a protocol using mice sta ...
Dr. Yuan, Hanna - May, 2023
Mammalian DNA methyltransferases (DNMTs), including DNMT1, DNMT3A, and DNMT3B, are key DNA methylation enzymes and play important roles in gene expression regulation. Dysregulation of DNMTs is linked ...
Dr. Tsay, Yi-Fang - April, 2023
The photorespiratory intermediate glycerate is known to be shuttled between the peroxisome and chloroplast. Here, localization of NPF8.4 in the tonoplast, together with the reduced vacuolar glycerate ...