科學發表
Dr. Yuan, Hanna S. - May, 2026
Asymmetric dimeric assembly of Suv3 helicase facilitates processive RNA unwinding
Nature Communications (2026)
Human Suv3 is a dimeric helicase that collaborates with the exoribonuclease PNPase to mediate RNA decay and surveillance in mitochondria. Despite its pivotal role in maintaining mitochondrial homeosta ...
Dr. Wu, Yu-Wei - May, 2026
Ultrasensitive measurement of brain penetration mechanics and blood vessel rupture with microscale probes
Proc Natl Acad Sci U S A . 2026 Mar 31;123(13):e2529147123.
Implanting microscale neural probes is central to neuroscience research and emerging brain-computer interfaces, yet the mechanical process by which tiny probes pass through living brain tissue has rem ...
Dr. Yuan, Hanna - May, 2026
Human Endonuclease G Preferentially Cleaves Oxidatively Damaged DNA
Biochemistry 65, 1427-1435 (2026)
Endonuclease G (EndoG) is a conserved endonuclease implicated in mitochondrial DNA (mtDNA) replication, maintenance of mtDNA integrity under oxidative stress, and the removal of nuclear and paternal m ...
Dr. Chen, Liuh-Yow - April, 2026
Orphan nuclear receptors recruit TRIM28 to promote telomeric H3K9me3 for the ALT pathway
The EMBO Journal
Cancer cells can use the alternative lengthening of telomeres (ALT) pathway to maintain telomere length, bypass cellular senescence, and achieve replicative immortality. However, the mechanism unde ...
Dr. Hsia, Kuo-Chiang - March, 2026
Cell Cycle-Specific Regulation of Centrosome Clustering Dynamics in Cancer Cells by the Multifunctional Kinesin HSET
Advanced Science
Centrosome amplification in cancer cells generates excess centrosomes that must cluster to enable bipolar cell division. Here, we demonstrate that the mitotic kinesin HSET actively transports condensa ...
Dr. Lin, Chien-Ling and Leu, Jun-Yi - February, 2026
Splicing regulation and intron evolution in the short-intron ciliate model of endosymbiosis Paramecium bursaria
Nucleic Acids Research
The integration of symbionts into host cells during endosymbiosis significantly alters gene expression and cell physiology. Though alternative splicing facilitates cellular adaptation through rapid mo ...
Dr. Yen, Hsueh-Chi - February, 2026
Protein C-Terminal Variations Impact Proteostasis
Nature Communications
Protein C-termini can vary due to errors or programmed regulation, contributing to proteome diversity, yet their impact on the proteome remains poorly understood. Although aberrant C-termini are often ...
Dr. Chang, Wen - January, 2026
Cryo-EM structure of the vaccinia virus entry fusion complex reveals a multicomponent fusion machinery
Science Advances, 14 Jan 2026
Membrane fusion is essential for viral entry. Unlike class I-III fusion proteins, vaccinia virus (VACV) uses a multicomponent entry fusion complex (EFC). Using cryo–electron microscopy, we determined ...
Dr. Keita Kamino - January, 2026
E. coli chemosensing accuracy is not limited by stochastic molecule arrivals
Nature Physics (2026)
Organisms use specialized sensors to measure their environments, but the principles governing their accuracy are unknown. The bacterium Escherichia coli climbs chemical gradients at speeds bounded by ...
Dr. Hsueh, Yi-Ping - December, 2025
Low-dose mixtures of dietary nutrients ameliorate behavioral deficits in multiple mouse models of autism
PLOS Biology (selected for press release)
Autism spectrum disorder (ASD) is a group of heterogeneous, behaviorally defined neurodevelopmental conditions influenced by both genetic and environmental factors. Here, we show that supplementation ...
Dr. Hsueh, Yi-Ping - November, 2025
Shared and divergent alteration of whole-brain connectivity and sensory deficits in multiple autism mouse models
Molecular Psychiatry
Autism spectrum disorder (ASD) is a heterogeneous developmental disconnection syndrome. Identifying circuit deficits is crucial for understanding ASD etiology, yet the involvement of multiple brain re ...
Dr. Chien, Cheng-Ting - November, 2025
Splicing factor Sf3b1 facilitates maintenance of neuronal dendrites by modulating mitochondrial health
Cellular and Molecular Life Sciences.
The intricate process of dendritic arborization is essential for forming functional neural circuits, and many of the underlying molecular and cellular mechanisms have been uncovered. However, how they ...
Dr. Wang, Ting-Fang - November, 2025
Homologous recombination counteracts mismatch repair to promote fertility and genetic diversity
Trends in Genetics.
A research team led by Dr. Ting-Fang Wang published a research paper in the journal "Nucleic Acids Research" on September 3 this year. They found that several Baker’s yeast Saccharomyces cerevisiae pr ...
Dr. Leu, Jun-Yi - October, 2025
Environment-dependent mutualism–parasitism transitions in the incipient symbiosis between Tetrahymena utriculariae and Micractinium tetrahymenae
The ISME Journal 19(1): wraf203 (2025)
Mutualistic endosymbiosis is a cornerstone of evolutionary innovation, enabling organisms to exploit diverse niches unavailable to individual species. However, our knowledge about the early evolutiona ...
Dr. Cheng, Pei-Lin - September, 2025
Nuclear paxillin functions as a molecular switch for alternative splicing in neurons during a critical period of brain development
The EMBO Journal
During a critical period of postnatal brain development, neural circuits undergo significant refinement coincident with widespread alternative splicing of hundreds of genes, which undergo altered spli ...
Dr. Wang, Ting-Fang - September, 2025
Rad51, Rad54, and ZMM proteins antagonize the mismatch repair system to promote fertility of budding yeast intraspecies hybrid zygotes
Nucleic Acids Research
Rad51 and meiosis-specific Dmc1 catalyze homologous recombination (HR) between maternal and paternal chromosomes during meiosis in many sexual eukaryotes, generating three interhomolog (IH) recombinat ...
Dr. Lin-Chao, Sue - September, 2025
The RNA degradation enzyme RNase E is essential for early flagellar assembly in Escherichia coli
PNAS Nexus
Escherichia coli endoribonuclease E (RNase E), encoded by the essential rne gene and conserved across γ-Proteobacteria, plays a central role in RNA processing and decay. We show here ...
Dr. Cheng, Soo-Chen - September, 2025
New mechanistic insights into Prp22-mediated exon ligation and mRNA release
Nucleic Acids Research
The DExD/H-box RNA helicase Prp22 catalyzes mRNA release from the spliceosome, and has also been implicated in proofreading the 3’ splice site, preventing exon ligation of mutant pre-mRNAs. We unveil ...
Dr. Chang, Wen - August, 2025
Structural Dissection of Vaccinia G9 Identifies Residues Essential for Membrane Fusion and Complex Assembly
Journal of Virology
Vaccinia virus, a prototypical poxvirus, utilizes a unique multi-protein Entry Fusion Complex (EFC), comprising 11 components, to mediate membrane fusion during host cell entry. Although the crystal s ...
Dr. Lin-Chao, Sue - August, 2025
Comprehensive analysis of repetitive extragenic palindrome sequences identified in bacteria and archaea using a new web-based tool, RepRanger
mSphere
Repetitive extragenic palindromic (REP) sequences were first discovered in the intergenic regions of Escherichia coli and later found in phylogenetically distinct bacterial species. However, their bio ...