科學發表
Dr. Chen, Jun-An - April, 2025
Sertm2 is a conserved micropeptide that promotes GDNF-mediated motor neuron subtype specification
EMBO Rep (2025)26: 2013-2043
Small open-reading frame-encoded micropeptides within long noncoding RNAs (lncRNAs) are often overlooked due to their small size and low abundance. However, emerging evidence links these micropeptides ...
Dr. Hanna S. Yuan - March, 2025
Histone modification–driven structural remodeling unleashes DNMT3B in DNA methylation
Science Advances.
The DNA methyltransferase 3B (DNMT3B) plays a vital role in shaping DNA methylation patterns during mammalian development. DNMT3B is intricately regulated by histone H3 modifications, yet the dynamic ...
Dr. Liao, Nan-Shih - March, 2025
cGAS and STING in host myeloid cells are essential for effective cyclophosphamide treatment of advanced breast cancer
Cancers 2025, 17, 1130
Cyclophosphamide (CTX) treatment in vivo kills proliferating tumor cells by DNA crosslinking, however, suppression of tumor growth by CTX in several murine models requires CD8+ T c ...
Dr. Ting, See-Yeun - March, 2025
Surface-mediated bacteriophage defense incurs fitness tradeoffs for interbacterial antagonism
EMBO J (2025)
Bacteria in polymicrobial environments face threats from phages, competing bacteria, and predatory eukaryotes. While bacterial defenses protect against these threats, their tradeoffs remain underexplo ...
Dr. Yuan, Hanna - February, 2025
Structural insights into human PNPase in health and disease
Nucleic Acids Research (2025)
Human polynucleotide phosphorylase (hPNPase) is a 3′-to-5′ exoribonuclease located in mitochondria, where it plays crucial roles in RNA degradation and RNA import. Mutations in hPNPase can impair thes ...
Dr. Chen, Jun-An - February, 2025
Treating neuromuscular diseases: unveiling gene therapy breakthroughs and pioneering future applications
Journal of Biomedical Science 32, Article number: 30
In this review, we highlight recent advancements in adeno-associated virus (AAV)-based gene therapy for genetic neuromuscular diseases (NMDs), focusing on spinal muscular atrophy (SMA) and Duchenne mu ...
Dr. Yu, Su-May - February, 2025
Mitochondrial AOX1a and an H2O2 feed-forward signalling loop regulate flooding tolerance in rice
Plant Biotechnol J . 2025 Feb;23(2):395-411.
Flooding is a widespread natural disaster that causes tremendous yield losses of global food production. Rice is the only cereal capable of growing in aquatic environments. Direct seeding by which see ...
Dr. Lin, Chien-Ling - February, 2025
Multiplexed Assays of Human Disease-relevant Mutations Reveal UTR Dinucleotide Composition as a Major Determinant of RNA Stability
eLife Sciences
Revealing Sequence Determinants of RNA Degradation from Human Disease-relevant Mutations
RNA stability is a critical regulator of gene expression, yet its precise control mechanisms remai ...
Dr. Shen, Che-Kun James - January, 2025
Molecular switch of the dendrite-to-spine transport of TDP-43/FMRP-bound neuronal mRNAs and its impairment in ASD
Cell Mol Biol Lett. 2025 Jan 15;30(1):6.
This study highlights the importance of posttranslational modifications of RBPs, particularly FMRP, as a molecular switch that regulates the transport of specific mRNAs in response to synaptic acti ...
Dr. Cheng, Pei-Lin - January, 2025
ECM29/proteasome-mediated self-antigen generation by CNS-resident neuroglia promotes regulatory T cell activation
Cell Reports
Proteasomes generate antigenic peptides presented on cell surfaces—a process that, in neuroglia, is highly responsive to external stimuli. However, the function of the self-antigens presented by CNS p ...
Dr. Hsueh, Yi-Ping - January, 2025
Signaling in autism: Relevance to nutrients and sex
Current Opinion in Neurobiology 90:102962
Autism spectrum disorders (ASD) are substantially heterogeneous neuropsychiatric conditions with over a thousand associated genetic factors and various environmental influences, such as infection and ...
Dr. Hsueh, Yi-Ping and Wang, Ting-Fang - December, 2024
Does “Chromosome Envelope” Exist in Addition to the Cell Membrane and Nuclear Envelope?
Journal Of Lipid Research
During eukaryotic mitosis, sister chromatids first undergo condensation and individuation before being equally segregated into the two daughter cells. This process varies across species. In most fu ...
Dr. Leu, Jun-Yi - November, 2024
Protein moonlighting by a target gene dominates phenotypic divergence of the Sef1 transcriptional regulatory network in yeasts
Nucleic Acids Research
Transcriptional rewiring generates phenotypic novelty, acting as an important mechanism contributing to evolutionary development, speciation, and adaptation in all organisms. The phenotypic outcomes ( ...
Dr. Chen, Sheng-hong - November, 2024
Plausible, robust biological oscillations through allelic buffering
Cell Systems
We usually think that biological oscillators emerge from feedback interaction between two molecules just like two people dancing. Feng-Shu Hsieh and others in the Laboratory for Cell Dynamics in 中央研究院 ...
Dr. Yuan, Hanna - November, 2024
Molecular mechanisms for DNA methylation defects induced by ICF syndrome-linked mutations in DNMT3B
Protein Science
DNA methyltransferase 3B (DNMT3B) plays a crucial role in DNA methylation during mammalian development. Mutations in DNMT3B are associated with human genetic diseases, particularly immunodeficiency, c ...
Dr. Hsia, Kuo-Chiang - October, 2024
HURP binding to the vinca domain of β-tubulin accounts for cancer drug resistance
Nature Communications volume 15 (1), Article number: 8844
Vinca alkaloids, a class of tubulin-binding agent, are widely used in treating cancer, yet the emerging resistance compromises their efficacy. Hepatoma up-regulated protein (HURP), a microtubule-assoc ...
Dr. Chien, Cheng-Ting - August, 2024
Galectins induced from hemocytes bridge phosphatidylserine and N-glycosylated Drpr/CED-1 receptor during dendrite pruning
Nature Communications
During neuronal pruning, phagocytes engulf shed cellular debris to avoid inflammation and maintain tissue homeostasis. How phagocytic receptors recognize degenerating neurites had been unclear. Here, ...
Dr. Ting, See-Yeun - August, 2024
A whole-cell platform for discovering synthetic cell adhesion molecules in bacteria
Nature Communications
Developing programmable bacterial cell-cell adhesion is of significant interest due to its versatile applications. Current methods that rely on presenting cell adhesion molecules (CAMs) on bacterial s ...
Dr. Hsiao, Chwan-Deng - July, 2024
Unraveling the structure and function of a novel SegC protein interacting with the SegAB chromosome segregation complex in Archaea
Nucleic Acids Research
Genome segregation is a fundamental process that preserves the genetic integrity of all organisms, but the mechanisms driving genome segregation in archaea remain enigmatic. This study delved into the ...
Dr. Chen, Sheng-hong - July, 2024
Emergence of large-scale cell death through ferroptotic trigger waves
Nature
Large-scale cell death is commonly observed during organismal development and in human pathologies1,2,3,4,5. These cell death events extend over great distances to eliminate large populations of cells ...