Lymphocyte Development and Function
I. 毒殺型淋巴球之免疫記憶
我們先前的研究發現若在活化CD8 型淋巴球時給予IL-4， 就會使得活化過的細胞「長壽」且具有殺毒功能。這個發現 建立了一個新觀念：淋巴球的壽命可以被活化的環境決定。 目前正在進行的相關研究有：（一）肝臟對CD8 T 淋巴細胞 記憶衡定所扮演的角色；（二）記憶型CD8 淋巴球homing pattern 之調控；（三）補助刺激（costimulation）對於形成記 憶型淋巴球所扮演的角色。
II. 以ENU 基因突變鼠為來研究淋巴細胞之發育及功能
目前正積極的進行H2-Aα這個ENU 突變鼠的研究，包含 CD4 淋巴細胞發育以及其在週邊免疫反應對於H2-Aα量之 不等需求、自體抗體產生機制、CD4 淋巴細胞之功能、和B 淋巴細胞抗原受體之訊息傳遞的缺陷。
- PDF, 1978-1982, Lab. Immunol., NIAID, NIH, USA
- Ph.D., 1978, Dept. Microbio. Immunol. U. Colorado Med. Sch., USA
- BS, 1974, Dept. Biology, Illinois Inst. Tech., USA
- Huang, L.-R., Chen, F.-L., Chen, Y.-T., Kung, J. T. (2000) Potent induction of long-term CD8+ T cell memory by short-term IL-4 exposure during T cell receptor stimulation. Proc. Natl. Acad. Sci. USA 97: 3406-3411.
- Chen, Y.-T., Kung, J. T. (2005). CD1d-independent acquisition of prompt IL-4 gene inducibility in thymus CD161(NK1)-CD44lowCD4+CD8- T cells is associated with CDR3-diverse and biased Vβ2/Vβ 7/ Vβ 8/ Vα3.2 T cell receptor usage. J. Immunol. 175: 6537-6550.
- Su, Y.-C., Lee, C.-C., Kung, J. T. (2010) Effector function-deficient memory CD8+ T cells clonally expand in the liver and give rise to peripheral memory CD8+ T cells. J. Immunol. 185: 7498.
- Lee, C.-C., Kung, J. T. (2012) Marginal zone B cell is a major source of Il-10 in Listeria monocytogenes susceptibility. J. Immunol. 189: 3319.
- Chen, Y.-T., Su, Y.-C., Chang, M.-L., Tsai, P.-F., Kung, J. T. (2017) Low level MHC-II expression leads to suboptimal Th cell response, increased auto-aggression, and heightened cytokine inducibility. J. Immunol. 198: 1928-1943.
- Chen, Y.-T., Su, Y.-C., Kung, J. T. (2018) B cell development sans B cell receptor responsiveness due to unfolded protein response–triggered Mef2c protein degradation. J. Immunol. 201: 2885-2898.
- Chen, Y.-T., Kung, J. T. (2020) Rapid death of follicular B cells and Burkitt lymphoma cells effectuated by Xbp1s. J. Immunol. 204: 3236-3247.
