探討剪接反應的分子機制，揭露其反應的可塑性

剪接反應是經由兩步的轉酯反應在剪接體上完成。剪接體也可經由調節反應中心的構形來催化逆向及其他反應。
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Contact

Prof. Dr. Cheng, Soo-Chen

mbscc@ccvax.sinica.edu.tw

Original Publication

Chan, Shih-Peng, Kao, Der-I, Tsai, Wei-Yu and Cheng, Soo-Chen
The Prp19p-Associated Complex in Spliceosome Activation

Science 302, 279-282 (2003) - DOI

Tseng, Chi-Kang and Cheng, Soo-Chen
Both Catalytic Steps of Nuclear Pre-mRNA Splicing Are Reversible

Science 320, 1782-1784 (2008) - DOI