闡明了RNase E 如何識別其切割位置，發現降解體中含有烯醇化酶及其存在的生物學奧秘

在各種嚴峻生長環境下,大腸桿菌利用基因表達調控來決定其存活。林淑端博士發現核糖核酸酶E切割RNA序列和RNA降解體調控細菌厭氧生長的分子機制。
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Contact

Prof. Dr. Lin-Chao Sue

mbsue@gate.sinica.edu.tw

Original Publication

Kenneth J. McDowall, Vladimir R. Kaberdin, Se-Wei Wu, Stanley N. Cohen & Sue Lin-Chao
Site-specific RNase E cleavage of oligonucleotides and inhibition by stem–loops

Nature 374, 287-290 (1995) - DOI

Oleg N. Murashko and Sue Lin-Chao
Escherichia coli responds to environmental changes using enolasic degradosomes and stabilized DicF sRNA to alter cellular morphology

Proc Natl Acad Sci USA 114, E8025-E8034 (2017) - DOI