Director
Dr. Jun-Yi Leu 呂俊毅 博士
Distinguished Research Fellow and Acting Director
Education and Positions
- Distinguished Research Fellow, 2021~ , IMB AS
- Research Fellow, 2013-2021, IMB AS
- Associate Research Fellow, 2010-2013, IMB AS
- Assistant Research Fellow, 2006-2010, IMB AS
- PDF, 2000-2006, Dept. Dept. Mol. & Cell Biol., Harvard Univ., USA
- Ph.D., 1999, Dept. Mol. Cell, & Dev. Biol., Yale Univ., USA
- MS, 1990, Dept. Life Sciences, Natl. Tsing-Hua Univ.
- BS, 1988, Dept. Chemical Engineering, Natl. Tsing-Hua Univ.
Honors and Awards
- 2022, Ministry of Education Annual Academic Award (教育部學術獎)
- 2021, Ministry of Science and Technology Outstanding Research Award (科技部傑出研究獎)
- 2018, Outstanding Scholar Award, Foundation for the Advancement of Outstanding Scholarship (傑出人才發展基金會傑出人才講座)
- 2013, National Science Council Outstanding Research Award (國科會傑出研究獎)
- 2009, Academia Sinica Research Award for Junior Investigators in Taiwan, 2009 (中研院年輕學者著作獎)
- 2007, International Human Frontier Science Program (HFSP) Young Investigators’ Award (國際人類前沿科學計畫年輕研究學者獎)
Specialty
- Evolution and Genome Biolog
Selected Publications
- Nguyen T.N.G., Kamal, M.M., Lin, C.-L.* and Leu, J.-Y.* “Splicing regulation and intron evolution in the short-intron ciliate model of endosymbiosis Paramecium bursaria.” Nucleic Acids Research 54(3): gkag063 (2026).
- Kamal, M.M., Cheng, Y.-H., Chu, L.-W., Nguyen, P.T., Liu, C.-F.J., Liao, C.-W., Posch, T., and Leu, J.-Y.* “Environment-dependent mutualism-parasitism transitions in the incipient symbiosis between Tetrahymena utriculariae and Micractinium tetrahymenae” ISME J. 19(1): wraf203 (2025).
- Hsu, P.-C.*, Lu, T.-C., Hung, P.-H. and Leu, J.-Y.* “Protein moonlighting by a target gene dominates phenotypic divergence of the Sef1 transcription regulatory network in yeasts.” Nucleic Acids Res. 52(22): 13914-13930 (2024).
- Lin, W.-H., Opoc, F.J.G., Liao, C.-W., Roy, K.R., Steinmetz, L.M. and Leu, J.-Y.* “Histone deacetylase Hos2 regulates protein expression noise by potentially modulating the protein translation machinery.” Nucleic Acids Res. 52(13): 7556-7571 (2024).
- Lai, H.-Y., Yu, Y.-H., Jhou, Y.-T., Liao, C.-W. and Leu, J.-Y.* “Multiple intermolecular interactions facilitate rapid evolution of essential genes.” Nature Ecol. Evol. 7(5): 745-755 (2023).
- Swamy, K.B.S., Lee, H.-Y., Ladra, C., Liu, C.-F.J., Chao, J.-C., Chen, Y.-Y. and Leu, J.-Y.* “Proteotoxicity caused by perturbed protein complexes underlies hybrid incompatibility in yeast.” Nature Communications 13: 4394 (2022).
- Amine, A.A.A., Liao, C.-W., Hsu, P.-C., Opoc, F.J.G. and Leu, J.-Y.*, “Experimental evolution improves mitochondrial genome quality control in Saccharomyces cerevisiae and extends its replicative lifespan.” Current Biology 31(16): 3663-3670 (2021).
- Leu, J.-Y., Chang, S.-L., Chao, J.-C., Woods, L.C. and McDonald, M.J.* “Sex alters molecular evolution in diploid experimental populations of S. cerevisiae.” Nature Ecology Evolution 4(3): 453-460 (2020).
- You, S.-T., Jhou, Y.-T., Kao, C.-F. and Leu, J.-Y.* “Experimental evolution reveals a general role for the methyltransferase Hmt1 in noise buffering.” PLoS Biology 17(10): e3000433 (2019).
- McDonald, M.J.*, Yu, Y.-H., Guo, J.-F., Chong, S.-Y., Kao, C.-F. and Leu, J.-Y.* “Mutation at a distance caused by homopolymeric guanine repeats in Saccharomyces cerevisiae.” Science Advances 2: e1501033 (2016).
- Siegal, M.L.* and Leu, J.-Y.* “On the nature and evolutionary impact of phenotypic robustness mechanisms.” Annual Review of Ecology, Evolution, and Systematics 45: 495-517 (2014).
- Hsieh, Y.-Y., Hung, P.-H., Leu, J.-Y.* “Hsp90 regulates non-genetic variation in response to environmental stress.” Molecular Cell 50: 82-92 (2013).
- Chou, J.-Y., Hung Y.-S., Lin, K.-H., Lee, H.-Y. and Leu, J.-Y.* “Multiple molecular mechanisms cause reproductive isolation between three yeast species.” PLoS Biology 8(7): e1000432 (2010).
- Lee, H.-Y., Chou, J.-Y., Cheong, L., Chang, N.-H., Yang, S.-Y. and Leu, J.-Y. (2008) “Incompatibility of nuclear and mitochondrial genomes causes hybrid sterility between two yeast species.” Cell 135: 1065-1073.
Deputy Director
Dr. Hsia, Kuo-Chiang 夏國強
Research Fellow
