Scientific Publications
Dr. Yu, Su-May - April, 2024
A newly evolved rice-specific gene JAUP1 regulates jasmonate biosynthesis and signaling to promote root development and multi-stress tolerance
Plant Biotechnology Journal
Root architecture and function are critical for plants to secure water and nutrient supply from the soil, but environmental stresses alter root development. The phytohormone jasmonic acid (JA) regulat ...
Dr. Hsueh, Yen-Ping - April, 2024
The nematode-trapping fungus Arthrobotrys oligospora detects prey pheromones via G protein-coupled receptors
Nature Microbiology, 2024-04-22
Unraveling how a predatory fungus sense its nematode prey
The capability to sense and respond to the environment is essential for survival and fitness in all organisms. Recent studies hav ...
Dr. Chen, Jun-An - February, 2024
LncRNA Litchi is a regulator for harmonizing maturity and resilient functionality in spinal motor neurons
iScience 27, Issue 3, 15 March 2024, 109207
Long noncoding RNAs (lncRNAs) play pivotal roles in modulating gene expression during development and disease. Despite their high expression in the central nervous system (CNS), understanding the prec ...
Dr. Wang, Ting-Fang - February, 2024
Noncanonical usage of stop codons in ciliates expands proteins with structurally flexible Q-rich motifs
Elife, 2024 Feb 23:12:RP91405.
Serine(S)/threonine(T)-glutamine(Q) cluster domains (SCDs), polyglutamine (polyQ) tracts and polyglutamine/asparagine (polyQ/N) tracts are Q-rich motifs found in many proteins. SCDs often are intrinsi ...
Dr. Hsueh, Yi-Ping - February, 2024
Vcp overexpression and leucine supplementation extend lifespan and ameliorate neuromuscular junction phenotypes of a SOD1G93A-ALS mouse model
Human Molecular Genetics, ddae022
Many genes with distinct molecular functions have been linked to genetically heterogeneous amyotrophic lateral sclerosis (ALS), including SuperOxide Dismutase 1 (SOD1) and Valosin-Containing Protein ( ...
Dr. Hsueh, Yi-Ping - February, 2024
Improved CaP Nanoparticles for Nucleic Acid and Protein Delivery to Neural PrimaryCultures and Stem Cells
ACS Nano 2024
Efficiently delivering exogenous materials into primary neurons and neural stem cells (NSCs) has long been a challenge in neurobiology. Existing methods have struggled with complex protocols, unreliab ...
Dr. Hsueh, Yen-Ping - November, 2023
Key processes required for the different stages of fungal carnivory by a nematode-trapping fungus
PLOS Biology
Nematodes are ubiquitous in soil and are the most abundant animals on Earth. Some fungi have evolved the ability to prey on nematodes in nutrient-deficient environments. To gain deeper insights into t ...
Dr. Chang, Wen - November, 2023
Structural and functional analyses of viral H2 protein of the vaccinia virus entry fusion complex
Journal of Virology, Nov 17, 2023, e01343-23.
Virus-mediated membrane fusion involves conformational changes of the viral fusion protein to fuse the opposing viral and host lipid bilayers. Unlike all other known viruses that contain a single fusi ...
Dr. Chang, Wen - November, 2023
Structural and functional analysis of vaccinia viral fusion complex component protein A28 through NMR and molecular dynamic simulations
PLoS Pathogens, 19(11): e1011500.
Host cell entry of vaccinia virus (a poxvirus) proceeds through multiple steps that involve many viral proteins to mediate cell infection. Upon binding to cells, vaccinia virus membrane fuses with hos ...
Dr. Cheng, Soo-Chen - October, 2023
An ATP-independent role for Prp16 in promoting aberrant splicing
Nucleic Acids Research, gkad861
The DExD/H-box RNA helicase Prp16 plays a pivotal role in the splicing process. Following the branching reaction, it utilizes its ATP-dependent functions to facilitate exon ligation by displacing step ...
Dr. Li, Hsou-min - September, 2023
Chloroplast import motor subunits FtsHi1 and FtsHi2 are located on opposite sides of the inner envelope membrane
PNAS 120 (37) e2307747120
Protein import into chloroplasts is powered by ATP hydrolysis in the stroma. Establishing the identity and functional mechanism of the stromal ATPase motor that drives import is critical for understan ...
Dr. Hsia, Kuo-Chiang - September, 2023
Structural convergence endows nuclear transport receptor Kap114p with a transcriptional repressor function toward TATA-binding protein
Nature Communications volume 14, Article number: 5518
The transcription factor TATA-box binding protein (TBP) modulates gene expression in nuclei. This process requires the involvement of nuclear transport receptors, collectively termed karyopherin- ( ...
Dr. Hsueh, Yi-Ping - September, 2023
Autism-related KLHL17 and SYNPO act in concert to control activity-dependent dendritic spine enlargement and the spine apparatus
PLOS Biology 21: e3002274.
Dendritic spines, the tiny and actin-rich protrusions emerging from dendrites, are the subcellular locations of excitatory synapses in the mammalian brain that control synaptic activity and plasticity ...
Dr. Sun, Y. Henry - August, 2023
Phenotypic heterogeneity in human genetic diseases: ultrasensitivity‑mediated threshold effects as a unifying molecular mechanism
Journal of Biomedical Science (2023) 30-58
Phenotypic heterogeneity is very common in genetic systems and in human diseases and has important conse‑quences for disease diagnosis and treatment. In addition to the many genetic and non‑geneti ...
Dr. Shen, Che-Kun James - July, 2023
Hematopoietic Transfer of the Anti-Cancer and Lifespan-Extending Capabilities of A Genetically Engineered Blood System
eLife
A causal relationship exists among the aging process, organ decay and dis-function, and the occurrence of various diseases including cancer. A genetically engineered mouse model, termed EklfK74R/K74R ...
Dr. Cheng, Pei-Lin - June, 2023
DNA tension assays reveal that force-dependent integrin activation regulates neurite outgrowth in primary cortical neurons
Biomaterials Advances 150, July 2023, 213431
Biomechanical inputs are ubiquitously present in biological systems and are known to regulate various cell functions. In particular, neural cell development is sensitive to mechanical regulation, as t ...
Dr. Leu, Jun-Yi - May, 2023
Differential Hsp90-dependent gene expression is strain-specific and common among yeast strains
iScience 26(5): 106635 (2023)
Enhanced phenotypic diversity increases a population’s likelihood of surviving catastrophic conditions. Hsp90, an essential molecular chaperone and a central network hub in eukaryotes, has been obse ...
Dr. Hsueh, Yi-Ping - May, 2023
Quantification of the density and morphology of dendritic spines and synaptic protein distribution using Thy1-YFP transgenic mice
STAR PROTOCOLS
Synaptopathy, which encompasses morphological deficits and any abnormal protein distribution of synapses, is a critical feature of many neurological diseases. We here provide a protocol using mice sta ...
Dr. Yuan, Hanna - May, 2023
Mechanistic Insights into Harmine-Mediated Inhibition of Human DNA Methyltransferases and Prostate Cancer Cell Growth
ACS Chem. Biol. in press (2023)
Mammalian DNA methyltransferases (DNMTs), including DNMT1, DNMT3A, and DNMT3B, are key DNA methylation enzymes and play important roles in gene expression regulation. Dysregulation of DNMTs is linked ...
Dr. Tsay, Yi-Fang - April, 2023
Study of vacuole glycerate transporter NPF8.4 reveals a new role of photorespiration in C/N balance
Nature Plants (2023)
The photorespiratory intermediate glycerate is known to be shuttled between the peroxisome and chloroplast. Here, localization of NPF8.4 in the tonoplast, together with the reduced vacuolar glycerate ...