Scientific Publications
Dr. Wang, Ting-Fang - September, 2025
Rad51, Rad54, and ZMM proteins antagonize the mismatch repair system to promote fertility of budding yeast intraspecies hybrid zygotes
Nucleic Acids Research
Rad51 and meiosis-specific Dmc1 catalyze homologous recombination (HR) between maternal and paternal chromosomes during meiosis in many sexual eukaryotes, generating three interhomolog (IH) recombinat ...
Dr. Lin-Chao, Sue - September, 2025
The RNA degradation enzyme RNase E is essential for early flagellar assembly in Escherichia coli
PNAS Nexus
Escherichia coli endoribonuclease E (RNase E), encoded by the essential rne gene and conserved across γ-Proteobacteria, plays a central role in RNA processing and decay. We show her ...
Dr. Cheng, Soo-Chen - September, 2025
New mechanistic insights into Prp22-mediated exon ligation and mRNA release
Nucleic Acids Research
The DExD/H-box RNA helicase Prp22 catalyzes mRNA release from the spliceosome, and has also been implicated in proofreading the 3’ splice site, preventing exon ligation of mutant pre-mRNAs. We unvei ...
Dr. Chang, Wen - August, 2025
Structural Dissection of Vaccinia G9 Identifies Residues Essential for Membrane Fusion and Complex Assembly
Journal of Virology
Vaccinia virus, a prototypical poxvirus, utilizes a unique multi-protein Entry Fusion Complex (EFC), comprising 11 components, to mediate membrane fusion during host cell entry. Although the crystal s ...
Dr. Lin-Chao, Sue - August, 2025
Comprehensive analysis of repetitive extragenic palindrome sequences identified in bacteria and archaea using a new web-based tool, RepRanger
mSphere
Repetitive extragenic palindromic (REP) sequences were first discovered in the intergenic regions of Escherichia coli and later found in phylogenetically distinct bacterial species. However, their bio ...
Dr. Shen, Che-Kun James - August, 2025
Hypoxia‑induced genome‑wide DNA demethylation by DNMT3A and EMT of cancer cells
Cellular & Molecular Biology Letters (2025)30:95
Epigenetic alterations of DNA methylations and/or histone modifications cause substantial transcriptomic reprogramming in cancer cells during EMT and metastasis, which can be therapeutically target ...
Dr. Hsueh, Yen-Ping - July, 2025
Predation by nematode-trapping fungus triggers mechanosensory-dependent quiescence in Caenorhabditis elegans
iScience
Animals exhibit diverse behavioral adaptations to predation, driving coevolution across the Tree of Life. Using Caenorhabditis elegans as a genetic model organism, we investigated how nematodes respon ...
Dr. Huang, Kuo Hua - July, 2025
Integration of social and depth information during affiliative behavior in zebrafish
Current Biology
During social interactions, individuals interpret others' behaviors differently depending on their distance - too close or too far can alter perception. How animals integrate social cues (such as beha ...
Dr. Li, Hsou-min - June, 2025
High-efficiency leucoplast transit peptides for manipulating plastid protein production
Nature Plants
Plastids develop into nutrient-storing leucoplasts in seeds and roots. Efficient protein delivery is essential to modify biosynthetic processes in leucoplasts for human needs, but no effective transit ...
Dr. Hsueh, Yen-Ping - July, 2025
Cuticular collagens mediate cross-kingdom predator–prey interactions between trapping fungi and nematodes
PLoS Biology
Adhesive interactions, mediated by specific molecular and structural mechanisms, are fundamental to host–pathogen and predator–prey relationships, driving evolutionary dynamics and ecological inte ...
Dr. Ting, See-Yeun - June, 2025
An interbacterial cysteine protease toxin inhibits cell growth by targeting type II DNA topoisomerases GyrB and ParE
PLOS Biology (2025), 23(5):e3003208
Bacteria deploy a diverse arsenal of toxic effectors to antagonize competitors, profoundly influencing the composition of microbial communities. Previous studies have identified an interbacterial toxi ...
Dr. Chen, Jun-An - June, 2025
MiR-34 at the crossroads of SMA pathogenesis and therapy: Emerging biomarker and therapeutic target
Molecular Therapy Nucleic Acids
Spinal muscular atrophy (SMA) remains a devastating genetic disorder and the leading cause of infant mortality. It is linked to functional loss of the survival motor neuron 1 (SMN1) gene. Restorati ...
Dr. Wang, Ting-Fang and Hsueh, Yi-Ping - July, 2025
Sex-biased zinc responses modulate ribosomal protein expression, protein synthesis and social defects in Cttnbp2 mutant mice
Neurobiology of Disease 211:106932.
Autism spectrum disorders (ASD) are neurodevelopmental conditions influenced by genetic mutations, dietary factors, and sex-specific mechanisms, yet the interplay of these factors remains elusive. Her ...
Dr. Chen, Jun-An - April, 2025
The motor neuron m6A repertoire governs neuronal homeostasis and FTO inhibition mitigates ALS symptom manifestation
Nature Communications volume 16, Article number: 4063 (2025)
Amyotrophic lateral sclerosis (ALS) is a swiftly progressive and fatal neurodegenerative ailment marked by the degenerative motor neurons (MNs). Why MNs are specifically susceptible in predominantly s ...
Dr. Chen, Jun-An - April, 2025
Sertm2 is a conserved micropeptide that promotes GDNF-mediated motor neuron subtype specification
EMBO Rep (2025)26: 2013-2043
Small open-reading frame-encoded micropeptides within long noncoding RNAs (lncRNAs) are often overlooked due to their small size and low abundance. However, emerging evidence links these micropeptides ...
Dr. Hanna S. Yuan - March, 2025
Histone modification–driven structural remodeling unleashes DNMT3B in DNA methylation
Science Advances.
The DNA methyltransferase 3B (DNMT3B) plays a vital role in shaping DNA methylation patterns during mammalian development. DNMT3B is intricately regulated by histone H3 modifications, yet the dynamic ...
Dr. Liao, Nan-Shih - March, 2025
cGAS and STING in host myeloid cells are essential for effective cyclophosphamide treatment of advanced breast cancer
Cancers 2025, 17, 1130
Cyclophosphamide (CTX) treatment in vivo kills proliferating tumor cells by DNA crosslinking, however, suppression of tumor growth by CTX in several murine models requires CD8+ T c ...
Dr. Ting, See-Yeun - March, 2025
Surface-mediated bacteriophage defense incurs fitness tradeoffs for interbacterial antagonism
EMBO J (2025)
Bacteria in polymicrobial environments face threats from phages, competing bacteria, and predatory eukaryotes. While bacterial defenses protect against these threats, their tradeoffs remain underexplo ...
Dr. Yuan, Hanna - February, 2025
Structural insights into human PNPase in health and disease
Nucleic Acids Research (2025)
Human polynucleotide phosphorylase (hPNPase) is a 3′-to-5′ exoribonuclease located in mitochondria, where it plays crucial roles in RNA degradation and RNA import. Mutations in hPNPase can impair ...
Dr. Chen, Jun-An - February, 2025
Treating neuromuscular diseases: unveiling gene therapy breakthroughs and pioneering future applications
Journal of Biomedical Science 32, Article number: 30
In this review, we highlight recent advancements in adeno-associated virus (AAV)-based gene therapy for genetic neuromuscular diseases (NMDs), focusing on spinal muscular atrophy (SMA) and Duchenne mu ...