Molecular switch of the dendrite-to-spine transport of TDP-43/FMRP-bound neuronal mRNAs and its impairment in ASD

Dr. Shen, Che-Kun James - January, 2025

This study highlights the importance of posttranslational modifications of RBPs, particularly FMRP, as a molecular switch that regulates the transport of specific mRNAs in response to synaptic activity. The misregulation of this switch may contribute to the pathogenesis of FMRP-related neurodevelopmental disorders, including ASD.

The findings suggest a potential link between TDP-43, a protein associated with neurodegenerative diseases, and ASD. The study indicates that mutations or dysfunctions in TDP-43 could play a significant role in neurodevelopmental disorders.