Glia in the Drosophila Visual System
Our research interests focus on the regulation of glia differentiation and the role of glia in the development and maintenance of the Drosophila visual system. We have developed an ex vivo culture system for the long-term culture of fly eye disc, allowing us to follow and manipulate glia migration, proliferation and differentiation during the development of the fly visual system. We are focusing on a special glia subtype, the wrapping glia. We are studying how its lineage is segregated from the other glia lineages, how its differentiation is spatially and temporally regulated, and how does it affect the function and axon guidance of the photoreceptor neurons.
- PDF, 1986-1988, Department of Biology, Yale University, USA
- Ph.D., 1986, Division of Biology, California Institute of Technology, USA
- BS, 1978, Department of Botany, National Taiwan University
- 1999, Academia Sinica Early-Career Investigator Research Achievement Award
- 1999, 2004, Research Excellence Award, National Science and Technology Council
- 1999-2004, 2004-2009, Frontier Science Grant, National Science and Technology Council
- 2008, Academic Award of Ministry of Education
- 2008, Ho Chin-Tuei Outstanding Honorary Award in Basic Science
- Lee, Y.-M., Sun, Y. H. (2015) Maintenance of glia in the optic lamina is mediated by EGFR signaling by photoreceptors in adult Drosophila. PLoS Genetics 11(4): e1005187.
- Tsao, C. K., Ku, H. Y., Lee, Y. M., Huang, Y. F., Sun, Y. H. (2016) Long term ex vivo culture and live imaging of Drosophila larval imaginal discs. PLoS One 11(9): e0163744.
- Ku, H.-Y., Sun, Y. H. (2017) Notch-dependent epithelial fold determines boundary formation between developmental fields in the Drosophila antenna. PLoS Genetics 13(7): e1006898.
- Yeh, P.-A., Chu, W.-C., Liu, J.-Y., Sun, Y. H. (2018) Glial expression of disease-associated poly-glutamine proteins impairs the blood-brain barrier in Drosophila. Human Mol. Genet. 27: 2546–2562.
- Tsao, C.-K., Huang, Y. F., Sun, Y. H. (2020) Early lineage segregation of the retinal basal glia in the Drosophila eye disc. Scientific Reports 10: 18522.
