- Hsu HC, Hsu SP, Hsu FY, Chang M*, Chen JA*. (2024) LncRNA Litchi is a Regulator for Harmonizing Maturity and Resilient Functionality in Spinal Motor Neurons. iScience Volume 27, Issue 3, 15 March 2024, 109207.
- Chen TH, Chang SH, Wu YF, Yen YP, Hsu FY, Chen YC, Ming Y, Hsu HC, Su YC, Wong ST, Hung JH, Chiou SH, Jong YH*, Chen JA*. (2023) MiR34 Contributes to Spinal Muscular Atrophy and AAV9-mediated Delivery of MiR34a Ameliorates the Motor Deficits in SMA Mice. Molecular Therapy Nucleic Acids v32, 13 June, Pages 144-160.
This article is highlighted by Academia Sinica (English) (Chinese). It is also featured in a series of newspapers, inc libertytimes, udn, etc., and SMA News Today.
- Liau ES, Jin SQ, Chen YC, Liu WS, Calon M, Nedelec S, Nie Q*, Chen JA*. (2023) Single-cell Transcriptomic Analysis Unveils the Diversity within Mammalian Spinal Motor Neurons.Nature Communications 14, Article number: 46. (Editor highlight’s featured article)
This article is highlighted by Academia Sinica (English) (Chinese).
- Ma Q, Yang LY, Tolentino K, Wang GP, Zhao Y, Litzenburger UM, Shu QM, Zhu Lin, Yang C, Jiao HY, Zhang F, Li R, Tsai MC, Chen JA, Lai I, Li LJ, Chang HY. (2022) Inducible LncRNA Transgenic Mice Reveal Continual Role of HOTAIR in promoting Breast Cancer Metastasis. eLife(DOI: 10.7554/eLife.79126)
- Li CJ, Liau ES, Lee YH, Huang YZ, Liu ZY, Willems A, Garside V, McGlinn E, Chen JA*, Tian H*. (2021) MicroRNA Governs Bistable Cell Differentiation and Lineage Segregation via a Noncanonical Feedback.Mol Syst Biol 17:e9945 (Cover featured article).
- Chang SH, Su YC, Chang M, Chen JA*. (2021) MicroRNAs Mediate Precise Control of Spinal Interneuron Populations to Exert Delicate Sensory-to-motor Outputs.eLife(DOI: 10.7554/eLife.63768).
This article is selected as a showcase for featured eLife Science Digests, and the “Biomedical Picture of the Day” by MRC UK.
- Tung YT*, Peng KC, Chen, YC, Yen YP, Chang M, Thams S, Chen JA*. (2019) Mir-17~92 Confers Motor Neuron Subtype Differential Resistance to ALS-Associated Degeneration. Cell Stem Cell Aug 1;25(2):193-209 (Cover featured article).
- Yen YP, Hsieh WF, Tsia YY, Lu YL, Liau ES ,Hsu HC, Chen YC, Liu TC, Chang M, Li J, Lin SP*, Hung JH*, Chen JA*. (2018) Dlk1-Dio3 Locus-Derived LncRNAs Perpetuate Postmitotic Motor Neuron Cell Fate and Subtype Identity. eLife (DOI: 10.7554/eLife.38080).
- Liau ES, Yen YP, Chen JA*. (2018) Visualization of Motor Axon Navigation and Quantification of Axon Arborization In Mouse Embryos Using Light Sheet Fluorescence Microscopy. J. Vis. Exp. (135), e57546, doi:10.3791/57546.
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Li CJ, Hong T, Tung YT, Yen YP, Hsu HC, Lu YL, Chang M, Nie Q*, Chen JA*. (2017) MicroRNA filters Hox temporal transcription noise to confer boundary formation in the spinal cord. Nature Communications 8. Article number: 14685 (2017).
This article is highlighted by Academia Sinica (English)(Chinese), and on the Academia Sinica Facebook. It has also been featured in Asia Pacific Biotech News.
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Tung YT, Lu YL, Peng KC, Yen YP, Chang M, Li J, Jung H, Thams S, Huang YP, Hung JH, Chen JA*. (2015) Mir-17∼92 governs motor neuron subtype survival by mediating nuclear PTEN. Cell Reports. 2015 May 20. 10.1016/j.celrep.2015.04.050. (Cover featured article).
- Anderegg A, Lin H-P, Chen J-A, Caronia-Brown G, Cherepanova N, et al. (2013) An Lmx1b-miR135a2 regulatory circuit modulates Wnt1/Wnt signaling and determines the size of the midbrain dopaminergic progenitor pool. PLoS Genetics 9(12): e1003973. doi:10.1371/journal.pgen.1003973.
This paper is highlighted in the news of UTK.
This article has been recommended by F1000 by Andrew Yoo, 2019.
This article is selected as a showcase for featured eLife Science Digests. and the “Biomedical Picture of the Day” by MRC UK.
This article has been highlighted by Science Signaling Editor’s Choice, Alzforum.org, The ALS Forum, and PanScience (泛科學).
Before Academia Sinica
- Chen J-A* and Wichterle H*. (2012). Apoptosis of limb innervating motor neurons and erosion of motor pool identity upon lineage specific dicer inactivation, Frontiers in Neuroscience 6:69. doi: 10.3389/fnins.2012.00069. (Featured article).
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Chen J-A, Huang Y-P, Mazzoni EO, Zavadil J, Tan GC, and Wichterle H. (2011) Mir-17-3p controls spinal neural progenitor patterning by regulating Olig2/Irx3 cross-repressive loop, Neuron, 69(4). 721-35 (Featured article).
This article has been recommended by F1000 Bushati N, Briscoe J: 2011. F1000.com/8756957.
- Chen J-A, Chu S-T, and Amaya E. (2007) Maintenance of motor neuron progenitors in Xenopus requires a novel localized cyclin. EMBO Reports 8:287-292 (Featured article).
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Chen J-A, Voigt J, Gilchrist M, Papalopulu N and Amaya E. (2005) Identification of novel genes affecting mesoderm formation and morphogenesis through an enhanced large scale functional screen in Xenopus. Mechanisms of Development 122:307-331.
- Voigt J, Chen J-A, Gilchrist M, Amaya E and Papalopulu N. (2005) Expression cloning screening of a unique and full-length set of cDNA clones is an efficient method for identifying genes involved in Xenopus neurogenesis. Mechanisms of Development 122:289-306.
Featured article that made the cover poster
Patent and Technolgy Transfer
- MiR-17~92 as therapeutic or diagnostic target of motor neuron (mn) degeneration diseases. USA provisional patent (application no 62/652,127) (PCT/US19/25406).
Reviews and Books
- Yen YP* & Chen JA* (2021). The m6A epitranscriptome on Neural Development and Degeneration. Journal of Biomedical Science 28; Article number: 40.
- Chen KW & Chen JA* (2020). Functional Roles of Long Non-coding RNAs in Motor Neuron Development and Disease. Journal of Biomedical Science 27; Article number: 38.
- Chen TH & Chen JA* (2019). Multifaceted roles of MicroRNAs: From motor neuron generation in embryos to degeneration in spinal muscular atrophy. eLife 2019;8:e50848.
- Chen JA & Conn S. (2017). Canonical mRNA is the exception rather than the rule—Genome Biology 18:133.
