In our program, student learning takes place in research environment in which students benefit from interaction with researchers who are working at the frontiers of knowledge in their disciplines. Research is vigorous and pioneering and this creates a stimulating environment for study. Our staff are enthusiastic and committed to their subject. The enthusiasm and commitment generates an exciting and vibrant learning community.
The research in the Chromosome Biology focuses on the maintenance of chromosomes in cell division and the control of gene expression.
Projects cover virus entry and host cell signaling, virus replication and transcriptional control, protein engineering, T lymphocyte biology, and interleukin 15 activity, and bacterial physiology involving antibiotic target and resistance.
Focuses on the importance of gene function on cellular, organismic and developmental levels.
Projects cover interrogating neural development and degeneration by ES cells, neurodevelopmental disorders, Drosophila neural development and protein degradation control, mechanisms of motivation and memory, development of visual system, and prion biology.
Arabidopsis and rice are used as model systems to study plant physiology, plant gene regulation and its agricultural applications.
Focuses include mechanism of pre-mRNA splicing, RNA decay, regulation by noncoding RNA and RNA-associated diseases.
Macromolecular characteristics are being analyzed to unravel their structural-functional relationships by X-ray crystallographic, biophysical and biochemical approaches.
Research includes mechanisms of speciation and genetic buffering, interactions between nematodes and nematode-trapping fungi, cell growth and metabolic controls in the mammalian system, prokaryotes, protein turnover regulation and systems biology.
Molecular mechanism of vaccinia virus entry into mammalian hosts Cellular defense mechanisms and viral host range genes antagonizing host restriction
Baculovirus gene regulation and protein engineering; pseudotyped influenza virus studies and applications
Mechanisms of Eukaryotic Transcription
Non-coding RNA Function during Motor Neuron Development, Degeneration, and Regeneration
Telomere Biology and Telomere Diseases
Lab for Cell Dynamics aims to quantify and model dynamics of signaling networks in single cells as the basis to control cellular behavior for therapeutic purposes
Mechanisms of neuronal polarization and regeneration
Molecular mechanism of pre-mRNA splicing
Dendrite arborization in development and diseases
Synapse formation and plasticity
Steroid Regulation, Zebrafish Development, Disease Model, Gene Regulation
Molecular and structural basis of cell division
Hsiao, Chwan-Deng (David)
Structural and functional study of protein-DNA and protein-protein interaction by X-ray crystallography
Interactions between Nematodes and Nematode-trapping Fungi
Molecular biology of amyloid and prions
Structural principle of amyloids
Yeast genomics and experimental evolution
Cell-cell communication and gene network regulation
Genetic and noise buffering
Protein sorting within cells
Developmental regulation of protein trafficking
Intestine mucosal immunity
Anti-cancer immunity and immunotherapy
Signal pathways govern the control of bacterial RNA degradation;
Function of RNA degradosome components
Function of growth-arrest genes during mouse brain development
Genome-Wide Analysis of the mRNA Splicing and Translation
Molecular and neural mechanisms of motivation and memory
Molecular mechanism of Nitrate signaling and transport
Chromosome biology and fungal sexual development
Cytoskeleton and Organelle Biology
Mechanism of microtubule nucleation: r-TuRC assembly, targeting, and function in neuronal development
The molecular mechanism of flavivirus RNA replication: the role of viral RNA elements and virus nonstructural protein interactions
Neural circuit and glial network mechanisms underlying motor learning
Mechanisms of nutrient and O2 deficiency signaling in rice
Mechanisms of stress regulation of root development in rice
Structural and functional studies of DNA and RNA metabolism
Epigenetics, Protein post-translational modification, Transcriptional regulation
Metabolic regulation of cell growth and division in E.coli
Mechanism of bacterial cell wall synthesis
Neuronal communication and neurodegenerative diseases
Neural development, Developmental biology
Developmental Neurobiology, Neuronal circuitry, Insect Behavior
Cryo-electron microscopy and tomography
Developmental Biology, Stem cell Biology
Stem Cell Biology
Utilize genomic, metagenomics, and bioinformatics tools to investigate microbial genome evolution and the diversity
Genome-wide bypass of essential genes
Molecular mechanism of pre-mRNA splicing, mRNA export, and translation
In vivo roles of DExD/H-box proteins in RNA metabolism
Protein misfolding and neurodegenerative diseases
Hwang-Verslues, Wendy W.
Long term goals of the Hwang-Verslues laboratory are to decipher the links among circadian rhythm, core clock gene functions and stem cell (SC) fate/characteristics in tissue development and disease progression
Epigenetic Regulation in Development and Disease
The regulatory mechanisms in immune cell development and function
Lu, Joyce Jean
Efficiently reprogram somatic cell /stem cell fate by high throughput functional screens
Chen, Chien-Fu F.
Neurobiology of mammalian olfactory system
The casual relationship between inflammation and obesity-associated metabolic syndrome and diabetes mellitus ; The therapeutic approach to prevent and treat metabolic syndrome and type II diabetes
Nuclear receptor coactivator functions
Cancer biology and tumor microenvironment
Signal transduction and epigeneticregulation
Head and Neck Oncology
Molecular and genetic mechanism of the Hippo pathway in development and disease
Mechanisms and possible therapies of sepsis associated with septic shock, disseminated intravascular coagulation, or multiple organ failure
Cellular and Molecular Mechanisms of Fertilization ; Gametogenesis and Embryo Implantation in Mammals
Human inherited channelopathy and blood pressure regulation
Dr. Hsou-min Li / Program Coordinator (IMB)